Sublethal exposure of organophosphate pesticide chlorpyrifos alters cellular iron metabolism in hepatocytes and macrophages
文献类型：期刊论文
| 作者 | Sun, Li ; Zhang, Shuping ; Gu, Wenli ; He, Wei ; Qian, Yi ; Qu, Guangbo ; Ji, Hong ; Rong, Haiqin ; Liu, Sijin |
| 刊名 | INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
 |
| 出版日期 | 2014 |
| 卷号 | 34期号:5页码:1395-1400 |
| 关键词 | chlorpyrifos iron metabolism ferroportin hepcidin |
| ISSN号 | 1107-3756 |
| 中文摘要 | Chlorpyrifos (CPF) is commonly used for agricultural and domestic applications, and its contamination is widely detected in environmental media, and in a broad spectrum of field crops, fruits and vegetables. CPF exposure causes many adverse effects on human health including hepatoxicity, neurotoxicity and endocrine disruption. However, few studies have been conducted thus far to investigate the potential influence of CPF exposure on iron metabolism at concentrations that do not trigger significant cell death. Iron metabolism is concertedly governed by the hepcidin-ferroportin axis, where hepcidin is the central hormone involved in the regulation of iron absorption and release, while ferroportin is the only known iron exporter that functions by iron egress from cells. In the present study, we demonstrated that CPF treatment at a non-toxic concentration greatly enhanced ferroportin gene transcription in human macrophage THP-1 cells. CPF significantly inhibited hepcidin expression in human hepatocyte HepG2 cells. As a result, the intracellular labile iron pool (LIP) was largely reduced in THP-1 and HepG2 cells. The combined data of this study identified a novel finding of CPF that disrupts iron homeostasis by altering ferroportin and hepcidin expression. These findings would be useful in understanding the biological effects of CPF exposure, especially under relatively low and non-toxic doses. |
| WOS记录号 | WOS:000344423800026 |
| 公开日期 | 2015-03-24 |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/9466]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Sun, Li,Zhang, Shuping,Gu, Wenli,et al. Sublethal exposure of organophosphate pesticide chlorpyrifos alters cellular iron metabolism in hepatocytes and macrophages[J]. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE,2014,34(5):1395-1400. |
| APA | Sun, Li.,Zhang, Shuping.,Gu, Wenli.,He, Wei.,Qian, Yi.,...&Liu, Sijin.(2014).Sublethal exposure of organophosphate pesticide chlorpyrifos alters cellular iron metabolism in hepatocytes and macrophages.INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE,34(5),1395-1400. |
| MLA | Sun, Li,et al."Sublethal exposure of organophosphate pesticide chlorpyrifos alters cellular iron metabolism in hepatocytes and macrophages".INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 34.5(2014):1395-1400. |
入库方式： OAI收割
来源：生态环境研究中心
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