The first convergent total synthesis of penarolide sulfate A(2), a novel alpha-glucosidase inhibitor
文献类型：期刊论文
| 作者 | Gao, Yangguang ; Shan, Qiuli ; Liu, Jun ; Wang, Linlin ; Du, Yuguo |
| 刊名 | ORGANIC & BIOMOLECULAR CHEMISTRY
 |
| 出版日期 | 2014 |
| 卷号 | 12期号:13页码:2071-2079 |
| ISSN号 | 1477-0520 |
| 中文摘要 | Penarolide sulfate A(2), a 31-membered macrolide encompassing a proline residue and three sulfate groups, was firstly synthesized in 16 linear steps with 4.8% overall yield. Three consecutive stereogenic centers in penarolide sulfate A(2) were efficiently derived from natural chiral template L-arabinose. The crucial assembly reactions included Brown asymmetric allylation, olefin cross-metathesis, alkyne-epoxide coupling, and macrolactamization. The anti-yeast alpha-glucosidase activities of penarolide sulfate A(2) and its fully desulfated derivative were examined showing IC50 values of 4.87 and 10.74 mu g mL(-1), respectively. |
| WOS记录号 | WOS:000332457800010 |
| 公开日期 | 2015-03-24 |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/9472]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 生态环境研究中心_中国科学院环境生物技术重点实验室 |
| 推荐引用方式 GB/T 7714 | Gao, Yangguang,Shan, Qiuli,Liu, Jun,et al. The first convergent total synthesis of penarolide sulfate A(2), a novel alpha-glucosidase inhibitor[J]. ORGANIC & BIOMOLECULAR CHEMISTRY,2014,12(13):2071-2079. |
| APA | Gao, Yangguang,Shan, Qiuli,Liu, Jun,Wang, Linlin,&Du, Yuguo.(2014).The first convergent total synthesis of penarolide sulfate A(2), a novel alpha-glucosidase inhibitor.ORGANIC & BIOMOLECULAR CHEMISTRY,12(13),2071-2079. |
| MLA | Gao, Yangguang,et al."The first convergent total synthesis of penarolide sulfate A(2), a novel alpha-glucosidase inhibitor".ORGANIC & BIOMOLECULAR CHEMISTRY 12.13(2014):2071-2079. |
入库方式： OAI收割
来源：生态环境研究中心
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。