Thin Layer Chromatography Coupled with Surface-Enhanced Raman Scattering as a Facile Method for On-Site Quantitative Monitoring of Chemical Reactions
文献类型：期刊论文
| 作者 | Zhang, Zong-Mian ; Liu, Jing-Fu ; Liu, Rui ; Sun, Jie-Fang ; Wei, Guo-Hua |
| 刊名 | ANALYTICAL CHEMISTRY
 |
| 出版日期 | 2014 |
| 卷号 | 86期号:15页码:7286-7292 |
| ISSN号 | 0003-2700 |
| 中文摘要 | By coupling surface-enhanced Raman spectroscopy (SERS) with thin layer chromatography (TLC), a facile and powerful method was developed for on-site monitoring the process of chemical reactions. Samples were preseparated on a TLC plate following a common TLC procedure, and then determined by SEAS after fabricating a large-area, uniform SERS substrate on the TLC plate by spraying gold nanoparticles (AuNPs). Reproducible and strong SERS signals were obtained with substrates prepared by spraying 42-nm AuNPs at a density of 5.54 x 10(10) N/cm(2) on the TLC plate. The capacity of this TLC-SERS method was evaluated by monitoring a typical Suzuki coupling reaction of phenylboronic acid and 2-bromopyridine as a model. Results showed that this proposed method is able to identify reaction product that is invisible to the naked eye, and distinguish the reactant 2-bromopyridine and product 2-phenylpyridine, which showed almost the same retention factors (R-f). Under the optimized conditions, the peak area of the characteristic Raman band (755 cm(-1)) of the product 2-phenylpyridine showed a good linear correlation with concentration in the range of 2-200 mg/L (R-2 = 0.9741), the estimated detection limit (1 mg/L 2-phenylpyridine) is much lower than the concentration of the chemicals in the common organic synthesis reaction system, and the product yield determined by the proposed TLC-SERS method agreed very well with that by UPLC-MS/MS. In addition, a new byproduct in the reaction system was found and identified through continuous Raman detection from the point of sample to the solvent front. This facile TLC-SERS method is quick, easy to handle, low-cost, sensitive, and can be exploited in on-site monitoring the processes of chemical reactions, as well as environmental and biological processes. |
| WOS记录号 | WOS:000340081100023 |
| 公开日期 | 2015-03-24 |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/9480]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Zhang, Zong-Mian,Liu, Jing-Fu,Liu, Rui,et al. Thin Layer Chromatography Coupled with Surface-Enhanced Raman Scattering as a Facile Method for On-Site Quantitative Monitoring of Chemical Reactions[J]. ANALYTICAL CHEMISTRY,2014,86(15):7286-7292. |
| APA | Zhang, Zong-Mian,Liu, Jing-Fu,Liu, Rui,Sun, Jie-Fang,&Wei, Guo-Hua.(2014).Thin Layer Chromatography Coupled with Surface-Enhanced Raman Scattering as a Facile Method for On-Site Quantitative Monitoring of Chemical Reactions.ANALYTICAL CHEMISTRY,86(15),7286-7292. |
| MLA | Zhang, Zong-Mian,et al."Thin Layer Chromatography Coupled with Surface-Enhanced Raman Scattering as a Facile Method for On-Site Quantitative Monitoring of Chemical Reactions".ANALYTICAL CHEMISTRY 86.15(2014):7286-7292. |
入库方式： OAI收割
来源：生态环境研究中心
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