Tuning Cell Autophagy by Diversifying Carbon Nanotube Surface Chemistry
文献类型：期刊论文
| 作者 | Wu, Ling ; Zhang, Yi ; Zhang, Chengke ; Cui, Xuehui ; Zhai, Shumei ; Liu, Yin ; Li, Changlong ; Zhu, Hao ; Qu, Guangbo ; Jiang, Guibin ; Yan, Bing |
| 刊名 | ACS NANO
 |
| 出版日期 | 2014 |
| 卷号 | 8期号:3页码:2087-2099 |
| 关键词 | carbon nanotube surface modification mTOR autophagy combinatorial library signaling pathway |
| ISSN号 | 1936-0851 |
| 中文摘要 | The induction of autophagy by nanoparticles causes nanotoxicity, but appropriate modulation of autophagy by nanoparticles may have therapeutic potential. Multiwalled carbon nanotubes (MWCNTs) interact with cell membranes and membrane-associated molecules before and after internalization. These interactions alter cellular signaling and impact major cell functions such as cell cycle, apoptosis, and autophagy. In this work, we demonstrated that MWCNT-cell interactions can be modulated by varying densely distributed surface ligands on MWCNTs. Using a fluorescent autophagy-reporting cell line, we evaluated the autophagy induction capability of 81 surface-modified MWCNTs. We identified strong and moderate autophagy-inducing MWCNTs as well as those that did not induce autophagy. Variation of the surface ligand structure of strong autophagy nanoinducers led to the induction of different autophagy-activating signaling pathways, presumably through their different interactions with cell surface receptors. |
| WOS记录号 | WOS:000333539400023 |
| 公开日期 | 2015-03-24 |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/9485]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Wu, Ling,Zhang, Yi,Zhang, Chengke,et al. Tuning Cell Autophagy by Diversifying Carbon Nanotube Surface Chemistry[J]. ACS NANO,2014,8(3):2087-2099. |
| APA | Wu, Ling.,Zhang, Yi.,Zhang, Chengke.,Cui, Xuehui.,Zhai, Shumei.,...&Yan, Bing.(2014).Tuning Cell Autophagy by Diversifying Carbon Nanotube Surface Chemistry.ACS NANO,8(3),2087-2099. |
| MLA | Wu, Ling,et al."Tuning Cell Autophagy by Diversifying Carbon Nanotube Surface Chemistry".ACS NANO 8.3(2014):2087-2099. |
入库方式： OAI收割
来源：生态环境研究中心
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