Butachlor causes disruption of HPG and HPT axes in adult female rare minnow (Gobiocypris rarus)
文献类型：期刊论文
| 作者 | Zhu, Lifei ; Li, Wei ; Zha, Jinmiao ; Wang, Miao ; Yuan, Lilai ; Wang, Zijian |
| 刊名 | CHEMICO-BIOLOGICAL INTERACTIONS
 |
| 出版日期 | 2014 |
| 卷号 | 221期号:1页码:119-126 |
| 关键词 | Butachlor Plasma hormone Hypothalamic-pituitary-gonadal (HPG) axis Hypothalamic-pituitary-thyroid (HPT) axis Rare minnow (Gobiocypris rarus) |
| ISSN号 | 0009-2797 |
| 中文摘要 | Butachlor is a chloroacetamide herbicide widely used in Asia, and may enter the aquatic environment through agricultural application. In this study, plasma VTG and hormone levels (E2, 11-KT, T3 and T4) were determined after the female rare minnow (Gobiocypris rarus) was exposed to butachlor at environmental relevant concentrations (0, 0.1, 1, and 10 mu g/L) for 40 days. The mRNA levels of the HPG axis-related genes (gnrh, er alpha, vtg, star, lhr, 3 beta-hsd, cyp11a, cyp17, cyp19a and cyp19b), and the HPT axis-related genes (tr alpha, dio1, dio2, and dio3) were quantified after 20 and 40 days exposure to butachlor. For the HPG axis, the plasma 11-KT was increased at exposure concentration of 10 mu g/L, and VTG was significantly decreased at 1 mu g/L. Functional genes like gnrh and cyp19b in the brains, star, lhr, cyp11a, 3 beta-hsd, and cyp19a in the ovaries, and era and vtg in livers were up-regulated. For the HPT axis, the results showed that plasma T4 levels were significantly increased, the gene expression of dio1 was up-regulated, dio2 showed no significant variation, and dio3 was down-regulated in the livers. These results indicated that butachlor may promote the accumulation of T4 in fish through inactive deiodinase type 3. The transcription of HPG axis-related genes could serve as an auto-regulation of hormone levels after exposure to butachlor. Furthermore, the activation of gnrh may play an important role as a feed-back mechanism in the regulation of hormone levels and crosstalk of endocrine axes. (C) 2014 Elsevier Ireland Ltd. All rights reserved. |
| WOS记录号 | WOS:000345950500013 |
| 公开日期 | 2015-03-26 |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/9505]  |
| 专题 | 生态环境研究中心_环境水质学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Zhu, Lifei,Li, Wei,Zha, Jinmiao,et al. Butachlor causes disruption of HPG and HPT axes in adult female rare minnow (Gobiocypris rarus)[J]. CHEMICO-BIOLOGICAL INTERACTIONS,2014,221(1):119-126. |
| APA | Zhu, Lifei,Li, Wei,Zha, Jinmiao,Wang, Miao,Yuan, Lilai,&Wang, Zijian.(2014).Butachlor causes disruption of HPG and HPT axes in adult female rare minnow (Gobiocypris rarus).CHEMICO-BIOLOGICAL INTERACTIONS,221(1),119-126. |
| MLA | Zhu, Lifei,et al."Butachlor causes disruption of HPG and HPT axes in adult female rare minnow (Gobiocypris rarus)".CHEMICO-BIOLOGICAL INTERACTIONS 221.1(2014):119-126. |
入库方式： OAI收割
来源：生态环境研究中心
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。