Effects of the human antiepileptic drug carbamazepine on the behavior, biomarkers, and heat shock proteins in the Asian clam Corbicula fluminea
文献类型：期刊论文
| 作者 | Chen, Huihui ; Zha, Jinmiao ; Liang, Xuefang ; Li, Jiasu ; Wang, Zijian |
| 刊名 | AQUATIC TOXICOLOGY
 |
| 出版日期 | 2014 |
| 卷号 | 155期号:1页码:1-8 |
| 关键词 | Carbamazepine Corbicula fluminea Siphoning behavior Antioxidant enzymes Heat shock proteins |
| ISSN号 | 0166-445X |
| 中文摘要 | Carbamazepine (CBZ), an anticonvulsant and mood-stabilizing pharmaceutical, is a widespread contaminant in aquatic environments. In this study, the effects of chronic exposure to environmentally relevant CBZ concentrations were investigated in freshwater clams Corbicula fluminea. Adult C. fluminea were exposed to 0.5, 5, and 50 mu g/L of CBZ for 30 days, after which siphoning behavior (filtration rates), biomarker levels, and heat shock protein expression were measured. The filtration rates were significantly decreased (p<0.05) by 50 mu g/L CBZ treatment, indicating a negative impact on C fluminea health. Superoxide dismutase (SOD) and glutathione reductase (GR) activities were decreased, and catalase (CAT) activity and malondialdehyde (MDA) content were increased in the gills and digestive gland, suggesting that CBZ induced an oxidative effect. The levels of Hsp22, Hsp40, and Hsp70 mRNAs were also markedly induced after 5 or 50 mu g/L CBZ treatment (p<0.05), whereas Hsp60 and Hsp90 mRNAs in gills and Hsp60 mRNA in digestive gland were significantly repressed (p<0.05). Finally, the expression of Hsp70 protein was significantly increased (p<0.05) by 5 and 50 mu g/L exposure. In aggregate, these results confirm that environmentally relevant concentrations of CBZ can exert a negative effect on C. fluminea tissue at the molecular and protein level. (C) 2014 Elsevier B.V. All rights reserved. |
| WOS记录号 | WOS:000342245300001 |
| 公开日期 | 2015-03-26 |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/9535]  |
| 专题 | 生态环境研究中心_环境水质学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Chen, Huihui,Zha, Jinmiao,Liang, Xuefang,et al. Effects of the human antiepileptic drug carbamazepine on the behavior, biomarkers, and heat shock proteins in the Asian clam Corbicula fluminea[J]. AQUATIC TOXICOLOGY,2014,155(1):1-8. |
| APA | Chen, Huihui,Zha, Jinmiao,Liang, Xuefang,Li, Jiasu,&Wang, Zijian.(2014).Effects of the human antiepileptic drug carbamazepine on the behavior, biomarkers, and heat shock proteins in the Asian clam Corbicula fluminea.AQUATIC TOXICOLOGY,155(1),1-8. |
| MLA | Chen, Huihui,et al."Effects of the human antiepileptic drug carbamazepine on the behavior, biomarkers, and heat shock proteins in the Asian clam Corbicula fluminea".AQUATIC TOXICOLOGY 155.1(2014):1-8. |
入库方式： OAI收割
来源：生态环境研究中心
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。