Endocrine disrupting effects of benzotriazole in rare minnow (Gobiocypris rarus) in a sex-dependent manner
文献类型：期刊论文
| 作者 | Liang, Xuefang ; Wang, Miao ; Chen, Xi ; Zha, Jinmiao ; Chen, Huihui ; Zhu, Lifei ; Wang, Zijian |
| 刊名 | CHEMOSPHERE
 |
| 出版日期 | 2014 |
| 卷号 | 112期号:1页码:154-162 |
| 关键词 | Benzotriazole Rare minnow (Gobiocypris rarus) Histopathology Steroid hormone HPG axis-related genes Endocrine disruption |
| ISSN号 | 0045-6535 |
| 中文摘要 | Benzotriazole (BT), an anticorrosive agent, is widely used in industrial applications and household dish-washing agents. Despite its reported toxicity to aquatic organisms, little is known about its endocrine disrupting effects. In this study, adult Chinese rare minnows (Gobiocypris rarus) were exposed to 0.05, 0.5, and 5 mg L-1 BT for 28 d. The pathological damage in liver was associated with hypertrophy of the hepatocytes, nuclei pyknosis and vacuolization at 5 mg L-1 groups. Additionally, the degeneration of the ovary and the stimulation of spermatogenesis were observed at 5 mg L-1 groups. The plasma 17 beta-estradiol level was significantly increased in the males but decreased in the females at 5 mg L-1 (p < 0.05). In the brain, the up-regulation of CYP19B, GnRHs, and LH beta mRNA was detected across all doses (p < 0.05). In the gonad, the transcriptional levels of StAR, CYP11A, 3 beta HSD, CYP17, 17 beta HSD, and CYP19A were generally decreased in the males at 5 mg L-1 (p < 0.05), whereas these genes, except for 3 beta HSD, were significantly increased in females at all concentrations (p < 0.05). Moreover, the expression level of VTG in the livers from all exposure groups was significantly increased compared with controls (p < 0.05). Taken together, our results indicate that BT could adversely affect the rare minnows in a sex-dependent manner. (C) 2014 Elsevier Ltd. All rights reserved. |
| WOS记录号 | WOS:000340688300021 |
| 公开日期 | 2015-03-26 |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/9541]  |
| 专题 | 生态环境研究中心_环境水质学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Liang, Xuefang,Wang, Miao,Chen, Xi,et al. Endocrine disrupting effects of benzotriazole in rare minnow (Gobiocypris rarus) in a sex-dependent manner[J]. CHEMOSPHERE,2014,112(1):154-162. |
| APA | Liang, Xuefang.,Wang, Miao.,Chen, Xi.,Zha, Jinmiao.,Chen, Huihui.,...&Wang, Zijian.(2014).Endocrine disrupting effects of benzotriazole in rare minnow (Gobiocypris rarus) in a sex-dependent manner.CHEMOSPHERE,112(1),154-162. |
| MLA | Liang, Xuefang,et al."Endocrine disrupting effects of benzotriazole in rare minnow (Gobiocypris rarus) in a sex-dependent manner".CHEMOSPHERE 112.1(2014):154-162. |
入库方式： OAI收割
来源：生态环境研究中心
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