In vitro agonistic and antagonistic endocrine disrupting effects of organic extracts from waste water of different treatment processes
文献类型：期刊论文
| 作者 | Rao, Kaifeng ; Li, Na ; Ma, Mei ; Wang, Zijian |
| 刊名 | FRONTIERS OF ENVIRONMENTAL SCIENCE & ENGINEERING
 |
| 出版日期 | 2014 |
| 卷号 | 8期号:1页码:69-78 |
| 关键词 | waste water in vitro recombinant yeast assay ethoxyresorufin-O-deethylase (EROD) receptor endocrine |
| ISSN号 | 2095-2201 |
| 中文摘要 | Effluents from wastewater treatment plant (WWTP) have been reported to have a broad spectrum of endocrine disrupting compounds (EDCs). The majority of studies have focused on the occurrence of estrogenic activity, while ignoring nuclear hormone receptors (NRs) pathways. In the present study, a battery of in vitro yeast bioassays and a cell bioassay, including antagonistic and agonistic effects on estrogen receptor (ER), androgen receptor (AR), progesterone receptor (PR), estrogen-related receptor (ERR) and aryl hydrocarbon receptor (AHR), were conducted to evaluate the removal efficiencies of EDCs by different treatment processes of a WWTP located in Beijing. Estrogenic, anti-estrogenic, anti-androgenic, anti-progesteronic, anti-ERR and the activation of AHR activities were detected in samples from all treatment processes and the receiving water. The concentration of estrogenic contaminants with estradiol (E-2) equivalent concentrations ranged from 0.82 x 10(-9) to 3.54 x 10(-9)g E-2-EQ center dot L-1. The concentration of anti-estrogenic contaminants with 4-hydroxytamoxifen (4-OHT) equivalent concentrations ranged from 1.24 x 10(-6) to 2.36 x 10(-6) g 4-OHT-EQ center dot L-1. The concentration of anti-androgenic contaminants ranged from 2.21 x 10(-8) to 3.52 x 10(-6) g flutamide-EQ center dot L-1. The concentration of anti-progesteronic contaminants ranged from 3.15 x 10(-5) to 2.71 x 10(-4) g RU486-EQ center dot L-1. The concentration of anti-ERR contaminants ranged from 7.09 x 10(-5) to 6.50 x 10(-4) g 4-OHT-EQ center dot L-1. The concentration of AHR activators ranged from 1.7 x 10(-10) to 3.4 x 10(-10) g TCDD-EQ center dot L-1. These processes including secondary clarifier, coagulation, as well as coal and sand filtration could eliminated 67.2% of estrogenic contaminants, 47.0% of anti-estrogenic contaminants, 98.3% of anti-androgenic contaminants, 88.4% of anti-progesteronic contaminants, 65.4% of anti-ERR contaminants and 46.9% of AHR activators. WWTP effluents contain multiple receptor disruptors may have very complex adverse effects on exposed organisms. |
| WOS记录号 | WOS:000330209000007 |
| 公开日期 | 2015-03-26 |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/9557]  |
| 专题 | 生态环境研究中心_环境水质学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Rao, Kaifeng,Li, Na,Ma, Mei,et al. In vitro agonistic and antagonistic endocrine disrupting effects of organic extracts from waste water of different treatment processes[J]. FRONTIERS OF ENVIRONMENTAL SCIENCE & ENGINEERING,2014,8(1):69-78. |
| APA | Rao, Kaifeng,Li, Na,Ma, Mei,&Wang, Zijian.(2014).In vitro agonistic and antagonistic endocrine disrupting effects of organic extracts from waste water of different treatment processes.FRONTIERS OF ENVIRONMENTAL SCIENCE & ENGINEERING,8(1),69-78. |
| MLA | Rao, Kaifeng,et al."In vitro agonistic and antagonistic endocrine disrupting effects of organic extracts from waste water of different treatment processes".FRONTIERS OF ENVIRONMENTAL SCIENCE & ENGINEERING 8.1(2014):69-78. |
入库方式： OAI收割
来源：生态环境研究中心
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