Long-term exposure investigating the estrogenic potency of estriol in Japanese medaka (Oryzias latipes)
文献类型：期刊论文
| 作者 | Lei, Bingli ; Kang, Jia ; Yu, Yingxin ; Zha, Jinmiao ; Li, Wei ; Wang, Zijian ; Wang, Yipei ; Wen, Yu |
| 刊名 | COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
 |
| 出版日期 | 2014 |
| 卷号 | 160期号:1页码:86-92 |
| 关键词 | Estriol Estrogenic potency Vitellogenin gene Estrogen receptor gene Environmentally relevant concentration Oryzias latipes |
| ISSN号 | 1532-0456 |
| 中文摘要 | The growth, development, and ERa and Vtg-I gene expressions of Japanese ricefish (Oryzias latipes; medaka) exposed to different concentrations of estriol (E3), including one environmentally relevant concentration, during embryo-adult life stages were evaluated. At the early life stage, fertilized eggs were exposed to 5, 50, 500, 5000 ng/L E3 for 15 days, and the hatched fry were exposed continuously to the same concentrations for an additional 15 days. Exposure to 500 and 5000 ng/L E3 resulted in adverse effects on hatchability and time to hatching. At 5000 ng/L, the gross abnormality rate was increased and the number of females that hatched was twice that of males. When the fish were exposed to 5-5000 ng/L E3 for further 60 days, the male hepatosomatic index (HSI) was increased at 5000 ng/L. The female gonadosomatic index (GSI) was decreased at 500 and 5000 ng/L E3, while the male GSI at 5000 ng/L E3 was increased and sex reversal was also found at this concentration. Quantitative RT-PCR showed that the hepatic vitellogenin-I (Vtg-I) genes were up-regulated in females at 500 and 5000 ng/L E3 and in males at all E3 concentrations, whereas E3 did not affect estrogen receptor alpha (ER alpha) mRNA transcription. These results showed that E3 at environmental concentration of 5 ng/L has no adverse effects on growth and development of the Japanese medaka. However, in this study, if we only focused on Vtg gene change in males, E3 had strong estrogenic effects on male medaka under the conditions of these experiments. (C) 2013 Elsevier Inc All rights reserved. |
| WOS记录号 | WOS:000330917400011 |
| 公开日期 | 2015-03-26 |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/9565]  |
| 专题 | 生态环境研究中心_环境水质学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Lei, Bingli,Kang, Jia,Yu, Yingxin,et al. Long-term exposure investigating the estrogenic potency of estriol in Japanese medaka (Oryzias latipes)[J]. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY,2014,160(1):86-92. |
| APA | Lei, Bingli.,Kang, Jia.,Yu, Yingxin.,Zha, Jinmiao.,Li, Wei.,...&Wen, Yu.(2014).Long-term exposure investigating the estrogenic potency of estriol in Japanese medaka (Oryzias latipes).COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY,160(1),86-92. |
| MLA | Lei, Bingli,et al."Long-term exposure investigating the estrogenic potency of estriol in Japanese medaka (Oryzias latipes)".COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY 160.1(2014):86-92. |
入库方式： OAI收割
来源：生态环境研究中心
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