Pyruvate carboxylase as a sensitive protein biomarker for exogenous steroid chemicals
文献类型：期刊论文
| 作者 | Liang, Xuefang ; Martyniuk, Christopher J. ; Cheng, Gang ; Zha, Jinmiao ; Wang, Zijian |
| 刊名 | ENVIRONMENTAL POLLUTION
 |
| 出版日期 | 2014 |
| 卷号 | 189期号:1页码:184-193 |
| 关键词 | Protein biomarker Pyruvate carboxylase Exogenous steroid chemicals Rare minnow |
| ISSN号 | 0269-7491 |
| 中文摘要 | Assessing protein responses to endocrine disrupting chemicals is critical for understanding the mechanisms of chemical action and for the assessment of hazards. In this study, the response of the liver proteome of male rare minnows (Gobiocypris rarus) treated with 17 beta-estradiol (E2) and females treated with 17 alpha-methyltestosterone (MT) were analyzed. A total of 23 and 24 proteins were identified with differential expression in response to E2 and MT, respectively. Pyruvate carboxylase (PC) was the only common differentially expressed protein in both males and females after E2- and MT-treatments. The mRNA as well as the protein levels of PC were significantly down-regulated compared with that of the controls (p < 0.05). Our results suggest that endocrine disruptors interfere with genes and proteins of the TCA cycle and PC may be a sensitive biomarker of exposure to exogenous steroid chemicals in the liver of fish. (C) 2014 Elsevier Ltd. All rights reserved. |
| WOS记录号 | WOS:000336466900024 |
| 公开日期 | 2015-03-26 |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/9588]  |
| 专题 | 生态环境研究中心_环境水质学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Liang, Xuefang,Martyniuk, Christopher J.,Cheng, Gang,et al. Pyruvate carboxylase as a sensitive protein biomarker for exogenous steroid chemicals[J]. ENVIRONMENTAL POLLUTION,2014,189(1):184-193. |
| APA | Liang, Xuefang,Martyniuk, Christopher J.,Cheng, Gang,Zha, Jinmiao,&Wang, Zijian.(2014).Pyruvate carboxylase as a sensitive protein biomarker for exogenous steroid chemicals.ENVIRONMENTAL POLLUTION,189(1),184-193. |
| MLA | Liang, Xuefang,et al."Pyruvate carboxylase as a sensitive protein biomarker for exogenous steroid chemicals".ENVIRONMENTAL POLLUTION 189.1(2014):184-193. |
入库方式： OAI收割
来源：生态环境研究中心
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