Simultaneous Determination of 24 Antidepressant Drugs and Their Metabolites in Wastewater by Ultra-High Performance Liquid Chromatography-Tandem Mass Spectrometry
文献类型：期刊论文
| 作者 | Zhang, Yu ; Yang, Min
|
| 刊名 | MOLECULES
 |
| 出版日期 | 2014 |
| 卷号 | 19期号:1页码:1212-1222 |
| 关键词 | pharmaceuticals antidepressants drug solid phase extraction wastewater treatment plants |
| ISSN号 | 1420-3049 |
| 中文摘要 | Antidepressants are a new kind of pollutants being increasingly found in wastewater. In this study, a fast and sensitive ultra-high performance liquid chromatography-tandem mass spectrometry method was developed and validated for the analysis of 24 antidepressant drugs and six of their metabolites in wastewater. This is the first time that the antidepressant residues in wastewater of Beijing (China) were systematically reported. A solid-phase extraction process was performed with 3 M cation disk, followed by ultra-high performance liquid chromatography-tandem mass spectrometry measurements. The chromatographic separation and mass parameters were optimized in order to achieve suitable retention time and good resolution for analytes. All compounds were satisfactorily determined in one single injection within 20 min. The limit of quantification (LOQ), linearity, and extraction recovery were validated. The LOQ for analytes were ranged from 0.02 to 0.51 ng/mL. The determination coefficients were more than 0.99 within the tested concentration range (0.1-25 ng/mL), and the recovery rate for each target compound was ranged from 81.2% to 118% at 1 ng/mL. This new developed method was successfully applied to analysis the samples collected from Beijing municipal wastewater treatment plants. At least ten target antidepressants were found in all samples and the highest mean concentration of desmethylvenlafaxin was up to 415.6 ng/L. |
| WOS记录号 | WOS:000334420300076 |
| 公开日期 | 2015-03-26 |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/9673]  |
| 专题 | 生态环境研究中心_中国科学院环境生物技术重点实验室 生态环境研究中心_环境水质学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Zhang, Yu,Yang, Min. Simultaneous Determination of 24 Antidepressant Drugs and Their Metabolites in Wastewater by Ultra-High Performance Liquid Chromatography-Tandem Mass Spectrometry[J]. MOLECULES,2014,19(1):1212-1222. |
| APA | Zhang, Yu,&Yang, Min.(2014).Simultaneous Determination of 24 Antidepressant Drugs and Their Metabolites in Wastewater by Ultra-High Performance Liquid Chromatography-Tandem Mass Spectrometry.MOLECULES,19(1),1212-1222. |
| MLA | Zhang, Yu,et al."Simultaneous Determination of 24 Antidepressant Drugs and Their Metabolites in Wastewater by Ultra-High Performance Liquid Chromatography-Tandem Mass Spectrometry".MOLECULES 19.1(2014):1212-1222. |
入库方式： OAI收割
来源：生态环境研究中心
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