Stereoselective metabolism, distribution, and bioaccumulation brof triadimefon and triadimenol in lizards
文献类型：期刊论文
| 作者 | Wang, Huili
|
| 刊名 | ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
 |
| 出版日期 | 2014 |
| 卷号 | 107期号:1页码:276-283 |
| 关键词 | Eremias argus Triadimefon Triadimenol Stereoselectivity |
| ISSN号 | 0147-6513 |
| 中文摘要 | In this research, Chinese lizards (Eremias argus) were chosen as laboratory animal to evaluate the stereoselectivity in the processes of metabolism, distribution, and bioaccumulation of triadimefon A validated chiral high-performance liquid chromatography coupled with triple quadruple mass spectrometry (HPLC-MS/MS) method was developed for determining enantiomers' residues of parent compound triadimefon and its metabolite triadimenol in lizard blood and tissues. Pharmacokinetic results of single-does exposure suggested that S-(+)-triadimefon was metabolized easier than R-(-)-triadimefon, and RR-(+)-triadimenol was the main metabolic product of triadimefon. During the continuous exposure of two dose (40 mg/kg(bw) . d and 200 mg/kg(bw) . d), enantiomers of triadimefon and triadimenol were detected in all body compartments, with the highest triadimefon concentrations in brain. However, the triadimenol concentrations were not significantly different among the compartments. The concentrations of RS-(+)-triadimenol were negative correlated with concentrations of RR-(+)-triadimenol both in blood (r= 0.775, p = 0.024) and liver (r= 0.834, p = 0.02) in 200 mg/kg(bw) . d group, which indicates that chiral conversion between enantiomers of triadimenol might exist in the metabolic process of triadimefon. In all the processes, the enantiomer fractions (EFs) of R-(-)-triadimefon and RR-(+)-triadimenol were significantly different from their natural ratios, 0.5 and 0.1, respectively, which proved that metabolism, bioaccumulation, and distribution of triadimefon and triadimenol in lizards were enantioselective. These results help enrich and supplement the knowledge of the stereoselective behaviour of triadimefon and triadimenol in reptile. (C) 2014 Elsevier Inc. All rights reserved. |
| WOS记录号 | WOS:000342122000038 |
| 公开日期 | 2015-03-26 |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/9675]  |
| 专题 | 生态环境研究中心_中国科学院环境生物技术重点实验室 |
| 推荐引用方式 GB/T 7714 | Wang, Huili. Stereoselective metabolism, distribution, and bioaccumulation brof triadimefon and triadimenol in lizards[J]. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,2014,107(1):276-283. |
| APA | Wang, Huili.(2014).Stereoselective metabolism, distribution, and bioaccumulation brof triadimefon and triadimenol in lizards.ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,107(1),276-283. |
| MLA | Wang, Huili."Stereoselective metabolism, distribution, and bioaccumulation brof triadimefon and triadimenol in lizards".ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY 107.1(2014):276-283. |
入库方式： OAI收割
来源：生态环境研究中心
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。