Combined effects of estrogenic chemicals with the same mode of action using an estrogen receptor binding bioassay
文献类型：期刊论文
| 作者 | Yang, Rong
|
| 刊名 | ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
 |
| 出版日期 | 2014 |
| 卷号 | 38期号:3页码:829-837 |
| 关键词 | Xenoestrogen Concentration addition Two-hybrid yeast assay Mixture toxicity Mode of action |
| ISSN号 | 1382-6689 |
| 中文摘要 | The increasing amounts of various estrogenic chemicals coexisting in the aquatic environment may pose environmental risks. While the concept of estradiol equivalent (EEQ) has been frequently applied in studying estrogenic mixtures, few experiments have been done to prove its reliability. In this study, the reliability of EEQ and the related model concentration addition (CA) was verified based on the two-hybrid recombinant yeast bioassay when all mixture components had the same mode of action and target of action. Our results showed that the measured estrogenic effects could be well predicted by CA and EEQ for all laboratory-made mixtures using two designs, despite the varying estrogenic activity, concentration levels and ratios of the test chemicals. This suggests that when an appropriate endpoint and its relevant bioassay are chosen, CA should be valid and the application of EEQ in predicting the effect of non-equi-effect mixtures is feasible. (C) 2014 Elsevier B.V. All rights reserved. |
| WOS记录号 | WOS:000347512400015 |
| 公开日期 | 2015-03-26 |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/9683]  |
| 专题 | 生态环境研究中心_中国科学院饮用水科学与技术重点实验室 生态环境研究中心_环境水质学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Yang, Rong. Combined effects of estrogenic chemicals with the same mode of action using an estrogen receptor binding bioassay[J]. ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY,2014,38(3):829-837. |
| APA | Yang, Rong.(2014).Combined effects of estrogenic chemicals with the same mode of action using an estrogen receptor binding bioassay.ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY,38(3),829-837. |
| MLA | Yang, Rong."Combined effects of estrogenic chemicals with the same mode of action using an estrogen receptor binding bioassay".ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY 38.3(2014):829-837. |
入库方式： OAI收割
来源：生态环境研究中心
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