Betaine homocysteine methyltransferase (BHMT) as a specific and sensitive blood marker for acute liver injury
文献类型：期刊论文
| 作者 | Ma, HL ; Ning, J ; Jin, X ; Mao, CM ; Bu, XL ; Wang, M ; Liu, H ; Wang, K ; Lausted, C ; Hood, L ; Chen, JK ; Hu, ZY |
| 刊名 | BIOMARKERS
 |
| 出版日期 | 2014 |
| 卷号 | 19期号:7页码:578—584 |
| 关键词 | ALANINE AMINOTRANSFERASE METHIONINE METABOLISM S-METHYLTRANSFERASE SERUM DISEASE ELISA ALT HEPATOTOXICITY VALIDATION EXPRESSION |
| ISSN号 | 1354-750X |
| 通讯作者 | mahuailei@nanoctr.cn ; 13366152125@163.com ; chenjiankui@hotmail.com ; huzy@nanoctr.cn |
| 英文摘要 | We developed a high-performance ELISA assay and measured serum BHMT levels in healthy individuals and patients with acute liver injury (ALI). The detection range of this ELISA assay was from 1.56 to 100 ng/ml. BHMT levels are significantly higher in ALI groups. In the healthy group (n = 244), the median value (interquartile range, IQR 0-56.40) was 1.83 ng/ml. In the ALI group (n = 42), the median value of BHMT was 748.48 ng/ml (IQR, 0-51095.92). ROC curve analysis demonstrated good sensitivity (0.86) and specificity (0.98). In addition, in five ALI cases with time course samples available, BHMT and ALT both followed the "rise and fall'' temporal pattern with the disease progression. However, the slopes of BHMT curves were steeper than ALT curves. And in three out of the five cases, BHMT levels peaked 1 day earlier than ALT levels be a sensitive marker with good prognostic value. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000344003400008 |
| 公开日期 | 2015-03-13 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/14024]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2011-2017年 |
| 推荐引用方式 GB/T 7714 | Ma, HL,Ning, J,Jin, X,et al. Betaine homocysteine methyltransferase (BHMT) as a specific and sensitive blood marker for acute liver injury[J]. BIOMARKERS,2014,19(7):578—584. |
| APA | Ma, HL.,Ning, J.,Jin, X.,Mao, CM.,Bu, XL.,...&Hu, ZY.(2014).Betaine homocysteine methyltransferase (BHMT) as a specific and sensitive blood marker for acute liver injury.BIOMARKERS,19(7),578—584. |
| MLA | Ma, HL,et al."Betaine homocysteine methyltransferase (BHMT) as a specific and sensitive blood marker for acute liver injury".BIOMARKERS 19.7(2014):578—584. |
入库方式： OAI收割
来源：上海应用物理研究所
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