CMOS-Compatible Silicon Nanowire Field-Effect Transistors for Ultrasensitive and Label-Free MicroRNAs Sensing
文献类型：期刊论文
| 作者 | Lu, N ; Gao, AR ; Dai, PF ; Song, SP ; Fan, CH ; Wang, YL ; Li, T |
| 刊名 | SMALL
 |
| 出版日期 | 2014 |
| 卷号 | 10期号:10页码:2022—2028 |
| 关键词 | ELECTRICAL DETECTION CANCER PATIENTS EXPRESSION BIOSENSORS RNAS NANOSENSORS ELEGANS GENES ACID DNA |
| ISSN号 | 1613-6810 |
| 通讯作者 | fchh@sinap.ac.cn ; ylwang@mail.sim.ac.cn ; tli@mail.sim.ac.cn |
| 英文摘要 | MicroRNAs (miRNAs) have been regarded as promising biomarkers for the diagnosis and prognosis of early-stage cancer as their expression levels are associated with different types of human cancers. However, it is a challenge to produce low-cost miRNA sensors, as well as retain a high sensitivity, both of which are essential factors that must be considered in fabricating nanoscale biosensors and in future biomedical applications. To address such challenges, we develop a complementary metal oxide semiconductor (CMOS)-compatible SiNW-FET biosensor fabricated by an anisotropic wet etching technology with self-limitation which provides a much lower manufacturing cost and an ultrahigh sensitivity. This nanosensor shows a rapid (< 1 minute) detection of miR-21 and miR-205, with a low limit of detection (LOD) of 1 zeptomole (ca. 600 copies), as well as an excellent discrimination for single-nucleotide mismatched sequences of tumor-associated miRNAs. To investigate its applicability in real settings, we have detected miRNAs in total RNA extracted from lung cancer cells as well as human serum samples using the nanosensors, which demonstrates their potential use in identifying clinical samples for early diagnosis of cancer. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000336611000019 |
| 公开日期 | 2015-03-13 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/14042]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2011-2017年 |
| 推荐引用方式 GB/T 7714 | Lu, N,Gao, AR,Dai, PF,et al. CMOS-Compatible Silicon Nanowire Field-Effect Transistors for Ultrasensitive and Label-Free MicroRNAs Sensing[J]. SMALL,2014,10(10):2022—2028. |
| APA | Lu, N.,Gao, AR.,Dai, PF.,Song, SP.,Fan, CH.,...&Li, T.(2014).CMOS-Compatible Silicon Nanowire Field-Effect Transistors for Ultrasensitive and Label-Free MicroRNAs Sensing.SMALL,10(10),2022—2028. |
| MLA | Lu, N,et al."CMOS-Compatible Silicon Nanowire Field-Effect Transistors for Ultrasensitive and Label-Free MicroRNAs Sensing".SMALL 10.10(2014):2022—2028. |
入库方式： OAI收割
来源：上海应用物理研究所
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