Crowdsourcing Yields a New Standard for Kinks in Protein Helices
文献类型：期刊论文
| 作者 | Wilman, HR ; Ebejer, JP ; Shi, JY ; Deane, CM ; Knapp, B |
| 刊名 | JOURNAL OF CHEMICAL INFORMATION AND MODELING
 |
| 出版日期 | 2014 |
| 卷号 | 54期号:9页码:2585—2593 |
| 关键词 | TRANSMEMBRANE HELICES SECONDARY STRUCTURE MEMBRANE-PROTEINS ALPHA-HELICES PROLINE GEOMETRY RESIDUE HINGES MODEL GAME |
| ISSN号 | 1549-9596 |
| 通讯作者 | knapp@stats.ox.ac.uk |
| 英文摘要 | Kinks are functionally important structural features found in the a-helices of proteins. Structurally, they are points at which a helix abruptly changes direction. Current kink definition and identification methods often disagree with one another. Here we describe a crowdsourcing approach to obtain a reliable gold standard set of kinks. Using an online interface, we collected more than 10 000 classifications of 300 helices into straight, curved, or kinked categories. We found that participants were better at discriminating between straight and not-straight helices than between kinked and curved helices. Surprisingly, more obvious kinks were not necessarily identified as more localized within the helix. We present a set of 252 helices where more than 50% of the participants agree on a classification. This set can be used as a reliable gold standard to develop, train, and compare computational methods. An interactive visualization of the results is available online at http://opig.stats.ox.ac.uk/webapps/ahah/php/experiment_results.php. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000342180400017 |
| 公开日期 | 2015-03-13 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/14061]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2011-2017年 |
| 推荐引用方式 GB/T 7714 | Wilman, HR,Ebejer, JP,Shi, JY,et al. Crowdsourcing Yields a New Standard for Kinks in Protein Helices[J]. JOURNAL OF CHEMICAL INFORMATION AND MODELING,2014,54(9):2585—2593. |
| APA | Wilman, HR,Ebejer, JP,Shi, JY,Deane, CM,&Knapp, B.(2014).Crowdsourcing Yields a New Standard for Kinks in Protein Helices.JOURNAL OF CHEMICAL INFORMATION AND MODELING,54(9),2585—2593. |
| MLA | Wilman, HR,et al."Crowdsourcing Yields a New Standard for Kinks in Protein Helices".JOURNAL OF CHEMICAL INFORMATION AND MODELING 54.9(2014):2585—2593. |
入库方式： OAI收割
来源：上海应用物理研究所
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