Cytotoxicity of silica nanoparticles on HaCaT cells
文献类型：期刊论文
| 作者 | Liang, H ; Jin, C ; Tang, Y ; Wang, FD ; Ma, CW ; Yang, YJ |
| 刊名 | JOURNAL OF APPLIED TOXICOLOGY
 |
| 出版日期 | 2014 |
| 卷号 | 34期号:4页码:367—372 |
| 关键词 | IN-VITRO OXIDATIVE STRESS MAGNETIC NANOPARTICLES CELLULAR UPTAKE GENE DELIVERY TOXICITY PARTICLES PROLIFERATION NANOMATERIALS GENOTOXICITY |
| ISSN号 | 0260-437X |
| 通讯作者 | chanjin1980@gmail.com |
| 英文摘要 | Despite the widespread use of silica nanoparticles (SiO2 NPs) in biological and medical fields, their adverse effects have not been clearly elucidated. In this study, spherical SiO2 NPs with a 50 nm diameter were used to study their interaction with HaCaT cells. SiO2 NPs were found to be readily internalized into HaCaT cells and localized in the cytoplasm, lysosomes and autophagosomes. Decreased cell viability and damaged cell membrane integrity showed the cytotoxicity of SiO2 NPs. Significant glutathione depletion and reactive oxygen species generation, which reduced the cellular antioxidant level, could be the major factor of cytotoxicity induced by SiO2 NPs. Copyright (c) 2013 John Wiley & Sons, Ltd. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000330314400005 |
| 公开日期 | 2015-03-13 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/14064]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2011-2017年 |
| 推荐引用方式 GB/T 7714 | Liang, H,Jin, C,Tang, Y,et al. Cytotoxicity of silica nanoparticles on HaCaT cells[J]. JOURNAL OF APPLIED TOXICOLOGY,2014,34(4):367—372. |
| APA | Liang, H,Jin, C,Tang, Y,Wang, FD,Ma, CW,&Yang, YJ.(2014).Cytotoxicity of silica nanoparticles on HaCaT cells.JOURNAL OF APPLIED TOXICOLOGY,34(4),367—372. |
| MLA | Liang, H,et al."Cytotoxicity of silica nanoparticles on HaCaT cells".JOURNAL OF APPLIED TOXICOLOGY 34.4(2014):367—372. |
入库方式： OAI收割
来源：上海应用物理研究所
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