Distribution of Graphene Oxide and TiO2-Graphene Oxide Composite in A549 Cells
文献类型：期刊论文
| 作者 | Jin, C ; Wang, FD ; Tang, Y ; Zhang, XZ ; Wang, JQ ; Yang, YJ |
| 刊名 | BIOLOGICAL TRACE ELEMENT RESEARCH
 |
| 出版日期 | 2014 |
| 卷号 | 159期号:42007页码:393—398 |
| 关键词 | MAGNETIC NANOPARTICLES CELLULAR UPTAKE CYTOTOXICITY ENDOCYTOSIS TOXICITY FILMS LINE |
| ISSN号 | 0163-4984 |
| 通讯作者 | chanjin1980@gmail.com ; yjyang22@gmail.com |
| 英文摘要 | Graphene and its derivatives are increasingly applied in nanoelectronics, biosensing, drug delivery, and biomedical applications. However, the information about its cytotoxicity remains limited. Herein, the distribution and cytotoxicity of graphene oxide (GO) and TiO2-graphene oxide composite (TiO2-GO composite) were evaluated in A549 cells. Cell viability and cell ultrastructure were measured. Our results indicated that GO could enter A549 cells and located in the cytoplasm and nucleus without causing any cell damage. TiO2 nanoparticles and GO would be separated after TiO2-GO composite entered A549 cells. TiO2-GO composite could induce cytotoxicity similar to TiO2 nanoparticles, which was probably attributed to oxidative stress. These results should be considered in the development of biological applications of GO and TiO2-GO composite. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000337284300048 |
| 公开日期 | 2015-03-13 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/14085]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2011-2017年 |
| 推荐引用方式 GB/T 7714 | Jin, C,Wang, FD,Tang, Y,et al. Distribution of Graphene Oxide and TiO2-Graphene Oxide Composite in A549 Cells[J]. BIOLOGICAL TRACE ELEMENT RESEARCH,2014,159(42007):393—398. |
| APA | Jin, C,Wang, FD,Tang, Y,Zhang, XZ,Wang, JQ,&Yang, YJ.(2014).Distribution of Graphene Oxide and TiO2-Graphene Oxide Composite in A549 Cells.BIOLOGICAL TRACE ELEMENT RESEARCH,159(42007),393—398. |
| MLA | Jin, C,et al."Distribution of Graphene Oxide and TiO2-Graphene Oxide Composite in A549 Cells".BIOLOGICAL TRACE ELEMENT RESEARCH 159.42007(2014):393—398. |
入库方式： OAI收割
来源：上海应用物理研究所
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