Gold nanostructures encoded by non-fluorescent small molecules in polyA-mediated nanogaps as universal SERS nanotags for recognizing various bioactive molecules
文献类型：期刊论文
| 作者 | Zhao, B ; Shen, JL ; Chen, SX ; Wang, DF ; Li, F ; Mathur, S ; Song, SP ; Fan, CH |
| 刊名 | CHEMICAL SCIENCE
 |
| 出版日期 | 2014 |
| 卷号 | 5期号:11页码:4460—4466 |
| 关键词 | ENHANCED RAMAN-SCATTERING SINGLE-STRANDED-DNA OPTICAL NANOPROBES CANCER-DETECTION OVARIAN-CANCER NANOPARTICLES HYBRIDIZATION SPECTROSCOPY NUCLEOSIDES BIOMARKERS |
| ISSN号 | 2041-6520 |
| 通讯作者 | spsong@sinap.ac.cn |
| 英文摘要 | Surface-enhanced Raman scattering (SERS) has recently been used to design novel nanoprobes called "SERS tags" which hold great promise for the fields of biosensing and nanomedicine. More recent advances have shed new light on the synthesis of uniform nanostructures with interior nanogaps for stable SERS enhancement. However, producing interior nanogap-based SERS nanotags directly and controllably with strong and stable multiplex SERS signals as well as developing a multiplex analytical platform to recognize different types of bioactive molecules still remain highly challenging. To address this challenge, we herein develop a novel approach for the direct synthesis of nanogap-based universal SERS nanotags by mediating poly-adenine (polyA) and encoding non-fluorescent small molecules. The universal nanotags were then functionalized by different types of biological probes and used as SERS nanoprobes to recognize various bioactive molecules. To the best of our knowledge, this is the first example of using SERS nanotags to develop a simultaneous multianalysis platform for all of the major types of bioactive analytes, including nucleic acids, proteins and small molecules. Furthermore, the nanotags show great promise for fluorescence-SERS bimodal bioanalysis and bioimaging. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000343004300043 |
| 公开日期 | 2015-03-13 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/14166]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2011-2017年 |
| 推荐引用方式 GB/T 7714 | Zhao, B,Shen, JL,Chen, SX,et al. Gold nanostructures encoded by non-fluorescent small molecules in polyA-mediated nanogaps as universal SERS nanotags for recognizing various bioactive molecules[J]. CHEMICAL SCIENCE,2014,5(11):4460—4466. |
| APA | Zhao, B.,Shen, JL.,Chen, SX.,Wang, DF.,Li, F.,...&Fan, CH.(2014).Gold nanostructures encoded by non-fluorescent small molecules in polyA-mediated nanogaps as universal SERS nanotags for recognizing various bioactive molecules.CHEMICAL SCIENCE,5(11),4460—4466. |
| MLA | Zhao, B,et al."Gold nanostructures encoded by non-fluorescent small molecules in polyA-mediated nanogaps as universal SERS nanotags for recognizing various bioactive molecules".CHEMICAL SCIENCE 5.11(2014):4460—4466. |
入库方式： OAI收割
来源：上海应用物理研究所
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