Influence of polyethylene glycol coating on biodistribution and toxicity of nanoscale graphene oxide in mice after intravenous injection
文献类型：期刊论文
| 作者 | Li, B ; Zhang, XY ; Yang, JZ ; Zhang, YJ ; Li, WX ; Fan, CH ; Huang, Q |
| 刊名 | INTERNATIONAL JOURNAL OF NANOMEDICINE
 |
| 出版日期 | 2014 |
| 卷号 | 9页码:4697—4707 |
| 关键词 | CHEMICAL-MODIFICATION CANCER-THERAPY DRUG-DELIVERY IN-VIVO NANOPARTICLE BIOCOMPATIBILITY INTERNALIZATION |
| ISSN号 | 1178-2013 |
| 通讯作者 | huangqing@sinap.ac.cn |
| 英文摘要 | In this study, we assessed the in vivo behavior and toxicology of nanoscale graphene oxide (NGO) in mice after intravenous injection. The influence of a polyethylene glycol (PEG) coating on the distribution and toxicity of the NGO was also investigated. The results show that NGO is mainly retained in the liver, lung, and spleen. Retention in the lung is partially due to NGO aggregation. The PEG coating reduces the retention of NGO in the liver, lung, and spleen and promotes the clearance of NGO from these organs, but NGO and NGO-PEG are still present after 3 months. The PEG coating effectively reduces the early weight loss caused by NGO and alleviates NGO-induced acute tissue injuries, which can include damage to the liver, lung, and kidney, and chronic hepatic and lung fibrosis. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000343164700001 |
| 公开日期 | 2015-03-13 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/14194]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2011-2017年 |
| 推荐引用方式 GB/T 7714 | Li, B,Zhang, XY,Yang, JZ,et al. Influence of polyethylene glycol coating on biodistribution and toxicity of nanoscale graphene oxide in mice after intravenous injection[J]. INTERNATIONAL JOURNAL OF NANOMEDICINE,2014,9:4697—4707. |
| APA | Li, B.,Zhang, XY.,Yang, JZ.,Zhang, YJ.,Li, WX.,...&Huang, Q.(2014).Influence of polyethylene glycol coating on biodistribution and toxicity of nanoscale graphene oxide in mice after intravenous injection.INTERNATIONAL JOURNAL OF NANOMEDICINE,9,4697—4707. |
| MLA | Li, B,et al."Influence of polyethylene glycol coating on biodistribution and toxicity of nanoscale graphene oxide in mice after intravenous injection".INTERNATIONAL JOURNAL OF NANOMEDICINE 9(2014):4697—4707. |
入库方式： OAI收割
来源：上海应用物理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。