Irreversible Denaturation of Proteins through Aluminum-Induced Formation of Backbone Ring Structures
文献类型：期刊论文
| 作者 | Song, B ; Sun, Q ; Li, HK ; Ge, BS ; Pan, JS ; Wee, ATS ; Zhang, Y ; Huang, SH ; Zhou, RH ; Gao, XY ; Huang, F ; Fang, HP |
| 刊名 | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
 |
| 出版日期 | 2014 |
| 卷号 | 53期号:25页码:6357—6363 |
| 关键词 | ALZHEIMERS-DISEASE ALPHA-SYNUCLEIN PROGRAM PACKAGE ACCUMULATION DIALYSIS BINDING HYDROXIDE ENERGY VIRUS BRAIN |
| ISSN号 | 1433-7851 |
| 通讯作者 | bosong@sinap.ac.cn ; xingyugao@sinap.ac.cn ; fhuang@upc.edu.cn |
| 英文摘要 | A combination of ab initio calculations, circular dichroism, nuclear magnetic resonance, and X-ray photoelectron spectroscopy has shown that aluminum ions can induce the formation of backbone ring structures in a wide range of peptides, including neurodegenerative disease related motifs. These ring structures greatly destabilize the protein and result in irreversible denaturation. This behavior benefits from the ability of aluminum ions to form chemical bonds simultaneously with the amide nitrogen and carbonyl oxygen atoms on the peptide backbone. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000337095900004 |
| 公开日期 | 2015-03-13 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/14206]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2011-2017年 |
| 推荐引用方式 GB/T 7714 | Song, B,Sun, Q,Li, HK,et al. Irreversible Denaturation of Proteins through Aluminum-Induced Formation of Backbone Ring Structures[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2014,53(25):6357—6363. |
| APA | Song, B.,Sun, Q.,Li, HK.,Ge, BS.,Pan, JS.,...&Fang, HP.(2014).Irreversible Denaturation of Proteins through Aluminum-Induced Formation of Backbone Ring Structures.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,53(25),6357—6363. |
| MLA | Song, B,et al."Irreversible Denaturation of Proteins through Aluminum-Induced Formation of Backbone Ring Structures".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 53.25(2014):6357—6363. |
入库方式： OAI收割
来源：上海应用物理研究所
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