Mesoporous magnesium silicate-incorporated poly(epsilon-caprolactone)-poly(ethylene glycol)-poly(epsilon-caprolactone) bioactive composite beneficial to osteoblast behaviors
文献类型：期刊论文
| 作者 | Niu, YF ; Dong, W ; Guo, H ; Deng, YH ; Guo, LP ; An, XF ; He, DW ; Wei, J ; Li, M |
| 刊名 | INTERNATIONAL JOURNAL OF NANOMEDICINE
 |
| 出版日期 | 2014 |
| 卷号 | 9页码:2665—2675 |
| 关键词 | SIMULATED BODY-FLUID DRUG-DELIVERY HYDROGEL RELEASE DEGRADATION SCAFFOLDS TEMPLATE IMPLANTS |
| ISSN号 | 1178-2013 |
| 通讯作者 | dyt901208@qq.com ; niuy1111@163.com |
| 英文摘要 | Mesoporous magnesium silicate (m-MS) and poly(epsilon-caprolactone)-poly(ethylene glycol)-poly(epsilon-caprolactone) (PCL-PEG-PCL) composite (m-MPC) was synthesized by solvent casting method. The results suggest that the mechanical properties of compressive strength and elastic modulus, as well as hydrophilicity, of the m-MPC increased with increase of m-MS content in the composites. In addition, the weight loss of the m-MPC improved significantly with the increase of m-MS content during composite soaking in phosphate-buffered saline for 10 weeks, indicating that incorporation of m-MS into PCL-PEG-PCL could enhance the degradability of the m-MPC. Moreover, the m-MPC with 40 w% m-MS could induce a dense and continuous apatite layer on its surface after soaking in simulated body fluid for 5 days, which was better than m-MPC 20 w% m-MS, exhibiting excellent in vitro bioactivity. In cell cultural experiments, the results showed that the attachment and viability ratio of MG63 cells on m-MPC increased significantly with the increase of m-MS content, showing that the addition of m-MS into PCL-PEG-PCL could promote cell attachment and proliferation. The results suggest that the incorporation of m-MS into PCL-PEG-PCL could produce bioactive composites with improved hydrophilicity, degradability, bioactivity, and cytocompatibility. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000336442700002 |
| 公开日期 | 2015-03-13 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/14244]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2011-2017年 |
| 推荐引用方式 GB/T 7714 | Niu, YF,Dong, W,Guo, H,et al. Mesoporous magnesium silicate-incorporated poly(epsilon-caprolactone)-poly(ethylene glycol)-poly(epsilon-caprolactone) bioactive composite beneficial to osteoblast behaviors[J]. INTERNATIONAL JOURNAL OF NANOMEDICINE,2014,9:2665—2675. |
| APA | Niu, YF.,Dong, W.,Guo, H.,Deng, YH.,Guo, LP.,...&Li, M.(2014).Mesoporous magnesium silicate-incorporated poly(epsilon-caprolactone)-poly(ethylene glycol)-poly(epsilon-caprolactone) bioactive composite beneficial to osteoblast behaviors.INTERNATIONAL JOURNAL OF NANOMEDICINE,9,2665—2675. |
| MLA | Niu, YF,et al."Mesoporous magnesium silicate-incorporated poly(epsilon-caprolactone)-poly(ethylene glycol)-poly(epsilon-caprolactone) bioactive composite beneficial to osteoblast behaviors".INTERNATIONAL JOURNAL OF NANOMEDICINE 9(2014):2665—2675. |
入库方式： OAI收割
来源：上海应用物理研究所
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