Molecular Recognition and Interaction between Uracil and Urea in Solid-State Studied by Terahertz Time-Domain Spectroscopy
文献类型：期刊论文
| 作者 | Yang, JQ ; Li, SX ; Zhao, HW ; Song, B ; Zhang, GX ; Zhang, JB ; Zhu, YM ; Han, JG |
| 刊名 | JOURNAL OF PHYSICAL CHEMISTRY A
 |
| 出版日期 | 2014 |
| 卷号 | 118期号:46页码:10927—10933 |
| 关键词 | DENSITY-FUNCTIONAL THEORY PROTON-TRANSFER REACTION NONCOVALENT INTERACTIONS INDUCED DENATURATION AQUEOUS UREA DNA DYNAMICS NUCLEOBASES COCRYSTALS ABSORPTION |
| ISSN号 | 1089-5639 |
| 通讯作者 | zhaohongwei@sinap.ac.cn ; jiaghan@tju.edu.cn |
| 英文摘要 | Using terahertz time-domain spectroscopy characterization, we observe that urea is able to recognize and interact with uracil efficiently even in the solid phase without involving water or solvents. A cocrystal configuration linked by a pair of hydrogen bonds between uracil and urea was formed. The terahertz absorption spectrum of the cocrystal shows a distinct new absorption at 0.8 THz (26.7 cm(1)), which originates from the intermolecular hydrogen bonding. Both mechanical milling and heating can accelerate the reaction efficiently. Density functional theory was adopted to simulate the vibrational modes of the cocrystal, and the results agree well with the experimental observation. Multiple techniques, including powder X-ray diffraction, scanning electron microscopy, and Fourier transform infrared spectroscopy, were performed to investigate the reaction process, and they presented supportive evidence. This work enables in-depth understanding of recognition and interaction of urea with nucleobases and comprehension of the denaturation related to RNA. We also demonstrate that terahertz spectroscopy is an effective and alternative tool for online measurement and quality control in pharmaceutical and chemical industries. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000345474500007 |
| 公开日期 | 2015-03-13 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/14249]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2011-2017年 |
| 推荐引用方式 GB/T 7714 | Yang, JQ,Li, SX,Zhao, HW,et al. Molecular Recognition and Interaction between Uracil and Urea in Solid-State Studied by Terahertz Time-Domain Spectroscopy[J]. JOURNAL OF PHYSICAL CHEMISTRY A,2014,118(46):10927—10933. |
| APA | Yang, JQ.,Li, SX.,Zhao, HW.,Song, B.,Zhang, GX.,...&Han, JG.(2014).Molecular Recognition and Interaction between Uracil and Urea in Solid-State Studied by Terahertz Time-Domain Spectroscopy.JOURNAL OF PHYSICAL CHEMISTRY A,118(46),10927—10933. |
| MLA | Yang, JQ,et al."Molecular Recognition and Interaction between Uracil and Urea in Solid-State Studied by Terahertz Time-Domain Spectroscopy".JOURNAL OF PHYSICAL CHEMISTRY A 118.46(2014):10927—10933. |
入库方式： OAI收割
来源：上海应用物理研究所
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