Morphological effect of oscillating magnetic nanoparticles in killing tumor cells
文献类型：期刊论文
| 作者 | Cheng, DF ; Li, X ; Zhang, GX ; Shi, HC |
| 刊名 | NANOSCALE RESEARCH LETTERS
 |
| 出版日期 | 2014 |
| 卷号 | 9 |
| 关键词 | IRON-OXIDE NANOPARTICLES POWER ABSORPTION THERMAL THERAPY SIZE HYPERTHERMIA TOXICITY SHAPE |
| ISSN号 | 1556-276X |
| 通讯作者 | zhangguoxin@sinap.ac.cn ; shi.hongcheng@zs-hospital.sh.cn |
| 英文摘要 | Forced oscillation of spherical and rod-shaped iron oxide magnetic nanoparticles (MNPs) via low-power and low-frequency alternating magnetic field (AMF) was firstly used to kill cancer cells in vitro. After being loaded by human cervical cancer cells line (HeLa) and then exposed to a 35-kHz AMF, MNPs mechanically damaged cell membranes and cytoplasm, decreasing the cell viability. It was found that the concentration and morphology of the MNPs significantly influenced the cell-killing efficiency of oscillating MNPs. In this preliminary study, when HeLa cells were pre-incubated with 100 mu g/mL rod-shaped MNPs (rMNP, length of 200 +/- 50 nm and diameter of 50 to 120 nm) for 20 h, MTT assay proved that the cell viability decreased by 30.9% after being exposed to AMF for 2 h, while the cell viability decreased by 11.7% if spherical MNPs (sMNP, diameter of 200 +/- 50 nm) were used for investigation. Furthermore, the morphological effect of MNPs on cell viability was confirmed by trypan blue assay: 39.5% rMNP-loaded cells and 15.1% sMNP-loaded cells were stained after being exposed to AMF for 2 h. It was also interesting to find that killing tumor cells at either higher (500 mu g/mL) or lower (20 mu g/mL) concentration of MNPs was less efficient than that achieved at 100 mu g/mL concentration. In conclusion, the relatively asymmetric morphological rod-shaped MNPs can kill cancer cells more effectively than spherical MNPs when being exposed to AMF by virtue of their mechanical oscillations. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000336280900001 |
| 公开日期 | 2015-03-13 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/14253]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2011-2017年 |
| 推荐引用方式 GB/T 7714 | Cheng, DF,Li, X,Zhang, GX,et al. Morphological effect of oscillating magnetic nanoparticles in killing tumor cells[J]. NANOSCALE RESEARCH LETTERS,2014,9. |
| APA | Cheng, DF,Li, X,Zhang, GX,&Shi, HC.(2014).Morphological effect of oscillating magnetic nanoparticles in killing tumor cells.NANOSCALE RESEARCH LETTERS,9. |
| MLA | Cheng, DF,et al."Morphological effect of oscillating magnetic nanoparticles in killing tumor cells".NANOSCALE RESEARCH LETTERS 9(2014). |
入库方式： OAI收割
来源：上海应用物理研究所
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