NANOTOXICITY OF MULTIWALL CARBON NANOTUBES TO A549 CELLS IN VITRO
文献类型：期刊论文
| 作者 | Wang, FD ; Zhang, H ; Jin, C ; Liang, H ; Tang, Y ; Yang, YJ |
| 刊名 | NANO
 |
| 出版日期 | 2014 |
| 卷号 | 9期号:2 |
| 关键词 | CEREBRAL-ISCHEMIA OXIDATIVE STRESS NEURONAL DEATH GENERATION RADICALS |
| ISSN号 | 1793-2920 |
| 通讯作者 | chanjin1980@gmail.com |
| 英文摘要 | Multiwall carbon nanotubes (MWCNTs) have been widely applied in many fields due to the excellent physical and chemical properties. As the production and applications of nanotubes expand, public concern about their potential risks to human health has also raised. Cytotoxicity of MWCNTs was evaluated in this study using a cultured human epithelial cell line A549. Uptake of MWCNTs by cultured A549 cells was observed by TEM imaging. Dose-dependent decrease of cell viability showed the cytotoxicity of MWCNTs. Significant reactive oxygen species (ROS) generation and GSH depletion which reduced the cellular antioxidant level could be the major factor of cytotoxicity induced by MWCNTs. MWCNTs seemed to trigger the activation of cell autophagy with the intracellular ATG16L1 level increase as a defense mechanism. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000339000100016 |
| 公开日期 | 2015-03-13 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/14266]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2011-2017年 |
| 推荐引用方式 GB/T 7714 | Wang, FD,Zhang, H,Jin, C,et al. NANOTOXICITY OF MULTIWALL CARBON NANOTUBES TO A549 CELLS IN VITRO[J]. NANO,2014,9(2). |
| APA | Wang, FD,Zhang, H,Jin, C,Liang, H,Tang, Y,&Yang, YJ.(2014).NANOTOXICITY OF MULTIWALL CARBON NANOTUBES TO A549 CELLS IN VITRO.NANO,9(2). |
| MLA | Wang, FD,et al."NANOTOXICITY OF MULTIWALL CARBON NANOTUBES TO A549 CELLS IN VITRO".NANO 9.2(2014). |
入库方式： OAI收割
来源：上海应用物理研究所
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