Pluronic-encapsulated natural chlorophyll nanocomposites for in vivo cancer imaging and photothermal/photodynamic therapies
文献类型：期刊论文
| 作者 | Chu, MQ ; Li, HK ; Wu, Q ; Wo, FJ ; Shi, DL |
| 刊名 | BIOMATERIALS
 |
| 出版日期 | 2014 |
| 卷号 | 35期号:29页码:8357—8373 |
| 关键词 | PHOTOTHERMAL THERAPY PHOTODYNAMIC THERAPY MAGNETIC-RESONANCE GRAPHENE OXIDE GOLD NANORODS MELANOMA EFFICACY NANOPARTICLES TUMORS CELLS |
| ISSN号 | 0142-9612 |
| 通讯作者 | mqchu98@tongji.edu.cn |
| 英文摘要 | A great challenge in developing nanotechnologies for cancer diagnosis and therapy has been the combined functionalities required for complicated clinical procedures. Among all requirements, toxicity has been the major hurdle that has prevented most of the nano-carriers from clinical use. Here, we extracted chlorophyll (Chl) from vegetable and encapsulated it into polymer (pluronic F68, Plu) micelles for cancer imaging and therapy. The results showed that the Chl-containing nanocomposites were capable of mouse tumor targeting, and the nanocomposite fluorescence within the tumor sites remained at high intensity more than two days after tail-vein injection. It is interesting that oral administration with the nanocomposites was also successful for tumor target imaging. Furthermore, the dietary Chl was found to be able to efficiently convert near-infrared laser irradiation to heat. The growths of melanoma cells and mouse tumors were effectively inhibited after being treated with the nanocomposites and irradiation. The suppression of the tumors was achieved by laser-triggered photothermal and photodynamic synergistic effects of Chl. As a natural substance from vegetable, Chl is non-toxic, making it an ideal nano-carrier for cancer diagnosis and treatment. Based on the results of this research, the Plu-Chl nanocomposites have shown promise for future clinical applications. (C) 2014 Elsevier Ltd. All rights reserved. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000340853400009 |
| 公开日期 | 2015-03-13 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/14319]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2011-2017年 |
| 推荐引用方式 GB/T 7714 | Chu, MQ,Li, HK,Wu, Q,et al. Pluronic-encapsulated natural chlorophyll nanocomposites for in vivo cancer imaging and photothermal/photodynamic therapies[J]. BIOMATERIALS,2014,35(29):8357—8373. |
| APA | Chu, MQ,Li, HK,Wu, Q,Wo, FJ,&Shi, DL.(2014).Pluronic-encapsulated natural chlorophyll nanocomposites for in vivo cancer imaging and photothermal/photodynamic therapies.BIOMATERIALS,35(29),8357—8373. |
| MLA | Chu, MQ,et al."Pluronic-encapsulated natural chlorophyll nanocomposites for in vivo cancer imaging and photothermal/photodynamic therapies".BIOMATERIALS 35.29(2014):8357—8373. |
入库方式： OAI收割
来源：上海应用物理研究所
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