Rational Design of pH-Controlled DNA Strand Displacement
文献类型：期刊论文
| 作者 | Amodio, A ; Zhao, B ; Porchetta, A ; Idili, A ; Castronovo, M ; Fan, CH ; Ricci, F |
| 刊名 | JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
 |
| 出版日期 | 2014 |
| 卷号 | 136期号:47页码:16469—16472 |
| 关键词 | LOGIC-CIRCUITS NUCLEIC-ACIDS IN-VITRO NANOSTRUCTURES NANOTECHNOLOGY NANOSWITCHES NANOMACHINES SPECIFICITY TOEHOLDS DEVICES |
| ISSN号 | 0002-7863 |
| 通讯作者 | francesco.ricci@uniroma2.it |
| 英文摘要 | Achieving strategies to finely regulate with biological inputs the formation and functionality of DNA-based nanoarchitectures and nanomachines is essential toward a full realization of the potential of DNA nanotechnology. Here we demonstrate an unprecedented, rational approach to achieve control, through a simple change of the solutions pH, over an important class of DNA association-based reactions. To do so we took advantage of the pH dependence of parallel Hoogsteen interactions and rationally designed two triplex-based DNA strand displacement strategies that can be triggered and finely regulated at either basic or acidic pHs. Because pH change represents an important input both in healthy and pathological biological pathways, our findings can have implication for the development of DNA nanostructures whose assembly and functionality can be triggered in the presence of specific biological targets. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000345720500003 |
| 公开日期 | 2015-03-13 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/14355]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2011-2017年 |
| 推荐引用方式 GB/T 7714 | Amodio, A,Zhao, B,Porchetta, A,et al. Rational Design of pH-Controlled DNA Strand Displacement[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,2014,136(47):16469—16472. |
| APA | Amodio, A.,Zhao, B.,Porchetta, A.,Idili, A.,Castronovo, M.,...&Ricci, F.(2014).Rational Design of pH-Controlled DNA Strand Displacement.JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,136(47),16469—16472. |
| MLA | Amodio, A,et al."Rational Design of pH-Controlled DNA Strand Displacement".JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 136.47(2014):16469—16472. |
入库方式： OAI收割
来源：上海应用物理研究所
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