Self-assembled polymeric micelles based on THP and THF linkage for pH-responsive drug delivery
文献类型：期刊论文
| 作者 | Zhu, FX ; Yang, QL ; Zhuang, Y ; Zhang, YQ ; Shao, ZF ; Gong, B ; Shen, YM |
| 刊名 | POLYMER
 |
| 出版日期 | 2014 |
| 卷号 | 55期号:13页码:2977—2985 |
| 关键词 | BLOCK-COPOLYMER MICELLES INTRACELLULAR DELIVERY ANTICANCER DRUG RELEASE NANOCARRIERS DOXORUBICIN DESIGN ACID MICELLIZATION NANOPARTICLES |
| ISSN号 | 0032-3861 |
| 通讯作者 | bgong@buffalo.edu ; yumeishen@sjtu.edu.cn |
| 英文摘要 | Developing smart nanocarriers for drug delivery system is advantageous for many kinds of successful biomedicinal therapy. In this study, we designed an amphiphilic block copolymers containing pH-responsive tetrahydropyran (THP) and tetrahydrofuran (THF) linkage. Their structures were confirmed by H-1 NMR and gel permeation chromatography (GPC). The release rate of encapsulated drugs depends upon the pH value and pH sensitive linkage in the backbone of copolymers. For PLA THP PEG micelles the cumulative relea,se amount of doxorubicin (DOX) was 62% at pH 5.0, which is about four times higher than that at pH 7.4. Under the same conditions the release rate for PLA THF PEG micelles is a little faster than that of the PLA THP PEG micelles. Cellular uptake study demonstrates that DOX-loaded micelles can easily enter the cells and produce the desired pharmacological action and minimizing the side effect of free DOX. These findings indicate that THP and THF linked diblock copolymer micelles is a promising candidate for drug carrier. (C) 2014 Elsevier Ltd. All rights reserved. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000337549000006 |
| 公开日期 | 2015-03-13 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/14377]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2011-2017年 |
| 推荐引用方式 GB/T 7714 | Zhu, FX,Yang, QL,Zhuang, Y,et al. Self-assembled polymeric micelles based on THP and THF linkage for pH-responsive drug delivery[J]. POLYMER,2014,55(13):2977—2985. |
| APA | Zhu, FX.,Yang, QL.,Zhuang, Y.,Zhang, YQ.,Shao, ZF.,...&Shen, YM.(2014).Self-assembled polymeric micelles based on THP and THF linkage for pH-responsive drug delivery.POLYMER,55(13),2977—2985. |
| MLA | Zhu, FX,et al."Self-assembled polymeric micelles based on THP and THF linkage for pH-responsive drug delivery".POLYMER 55.13(2014):2977—2985. |
入库方式： OAI收割
来源：上海应用物理研究所
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