中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Structural DNA Nanotechnology for Intelligent Drug Delivery

文献类型:期刊论文

作者Chao, J ; Liu, HJ ; Su, S ; Wang, LH ; Huang, W ; Fan, CH
刊名SMALL
出版日期2014
卷号10期号:22页码:4626—4635
关键词ROLLING CIRCLE AMPLIFICATION NANOSCALE SHAPES INTRACELLULAR DELIVERY ORIGAMI NANOSTRUCTURES TARGETED TRANSPORT GOLD NANOPARTICLES BRANCHED JUNCTIONS MOLECULAR DEVICES CELLULAR DELIVERY GENE-REGULATION
ISSN号1613-6810
通讯作者iamlhwang@njupt.edu.cn ; fchh@sinap.ac.cn
英文摘要Drug delivery carriers have been popularly employed to improve solubility, stability, and efficacy of chemical and biomolecular drugs. Despite the rapid progress in this field, it remains a great challenge to develop an ideal carrier with minimal cytotoxicity, high biocompatibility and intelligence for targeted controlled release. The emergence of DNA nanotechnology offers unprecedented opportunities in this regard. Due to the unparalleled self-recognition properties of DNA molecules, it is possible to create numerous artificial DNA nanostructures with well-defined structures and DNA nanodevices with precisely controlled motions. More importantly, recent studies have proven that DNA nanostructures possess greater permeability to the membrane barrier of cells, which pave the way to developing new drug delivery carriers with nucleic acids, are summarized. In this Concept, recent advances on the design and fabrication of both static and dynamic DNA nanostructures, and the use of these nanostructures for the delivery of various types of drugs, are highlighted. It is also demonstrated that dynamic DNA nanostructures provide the required intelligence to realize logically controlled drug release.
收录类别SCI
语种英语
WOS记录号WOS:000345366800012
公开日期2015-03-13
源URL[http://ir.sinap.ac.cn/handle/331007/14417]  
专题上海应用物理研究所_中科院上海应用物理研究所2011-2017年
推荐引用方式
GB/T 7714
Chao, J,Liu, HJ,Su, S,et al. Structural DNA Nanotechnology for Intelligent Drug Delivery[J]. SMALL,2014,10(22):4626—4635.
APA Chao, J,Liu, HJ,Su, S,Wang, LH,Huang, W,&Fan, CH.(2014).Structural DNA Nanotechnology for Intelligent Drug Delivery.SMALL,10(22),4626—4635.
MLA Chao, J,et al."Structural DNA Nanotechnology for Intelligent Drug Delivery".SMALL 10.22(2014):4626—4635.

入库方式: OAI收割

来源:上海应用物理研究所

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