Three-dimensional visualization of rat brain microvasculature following permanent focal ischaemia by synchrotron radiation
文献类型：期刊论文
| 作者 | Zhang, MQ ; Sun, DN ; Xie, YY ; Peng, GY ; Xia, J ; Long, HY ; Xiao, B |
| 刊名 | BRITISH JOURNAL OF RADIOLOGY
 |
| 出版日期 | 2014 |
| 卷号 | 87期号:1038 |
| ISSN号 | 0007-1285 |
| 关键词 | CEREBRAL-ARTERY OCCLUSION IN-VIVO ANGIOGENESIS ANGIOGRAPHY MICROANGIOGRAPHY REPERFUSION EXPRESSION MOUSE |
| 通讯作者 | xiaobo_xy@126.com |
| 英文摘要 | Objective: Identifying morphological changes that occur in microvessels under both normal and ischaemic conditions is crucial for understanding and treating stroke. However, conventional imaging techniques are not able to detect microvessels on a micron or sub-micron scale without angiography. In the present study, synchrotron radiation (SR)-based X-ray in-line phase contrast imaging (ILPCI) was used to acquire high-resolution and high-contrast images of rat brain tissues in both normal and ischaemic states. Methods: ILPCI was performed at the Shanghai Synchrotron Radiation Facility, Shanghai, China, without the use of contrast agents. CT slices were reformatted and then converted into three-dimensional (3D) reconstruction images to analyse subtle details of the cerebral microvascular network. Results: By using ILPCI, brain vessels up to 11.8 mu m in diameter were resolved. The number of cortical and penetrating arteries detected were found to undergo a remarkable decrease within the infarct area. 3 days after permanent ischaemia, vascular masses were also observed in the peripheral region of the infarcts. Conclusion: SR-based ILPCI-CT can serve as a powerful tool to accurately visualize brain microvasculature. The morphological parameters of blood vessels in both CT slices and 3D reconstructions were determined, and this approach has great potential for providing an effective diagnosis and evaluation for rehabilitation therapy for stroke. Advances in knowledge: In the absence of contrast agent, the 3D morphologies of the brain microvasculature in normal and stroke rats were obtained using SR-based ILPCI. SR imaging is a sensitive and promising method which can be used to explore primary brain function. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000339256600005 |
| 公开日期 | 2015-03-13 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/14512]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2011-2017年 |
| 推荐引用方式 GB/T 7714 | Zhang, MQ,Sun, DN,Xie, YY,et al. Three-dimensional visualization of rat brain microvasculature following permanent focal ischaemia by synchrotron radiation[J]. BRITISH JOURNAL OF RADIOLOGY,2014,87(1038). |
| APA | Zhang, MQ.,Sun, DN.,Xie, YY.,Peng, GY.,Xia, J.,...&Xiao, B.(2014).Three-dimensional visualization of rat brain microvasculature following permanent focal ischaemia by synchrotron radiation.BRITISH JOURNAL OF RADIOLOGY,87(1038). |
| MLA | Zhang, MQ,et al."Three-dimensional visualization of rat brain microvasculature following permanent focal ischaemia by synchrotron radiation".BRITISH JOURNAL OF RADIOLOGY 87.1038(2014). |
入库方式： OAI收割
来源：上海应用物理研究所
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