QSTR Studies on Acute Toxicity and Mutagenicity of Halogenated Benzenes
文献类型：期刊论文
| 作者 | Zhang, XL ; Zhou, ZX ; Fan, XL ; Liu, YH ; Li, HD ; Wang, JT |
| 刊名 | ASIAN JOURNAL OF CHEMISTRY
 |
| 出版日期 | 2014 |
| 卷号 | 26期号:9页码:2707 |
| ISSN号 | 0970-7077 |
| 关键词 | Halogenated benzenes Quantitative structure toxicity relationship Multiple linear regression Mutagenicity |
| 通讯作者 | Zhou, ZX (reprint author), Beijing Univ Technol, Coll Life Sci & Bioengn, Beijing 100124, Peoples R China. |
| 中文摘要 | In this paper, a quantitative structure toxicity relationship study was performed for the prediction of the acute toxicity and mutagenicity of halogenated benzenes. The molecular descriptors of halogenated benzenes have been calculated with semi-empirical AM1 and E-dragon methods and both quantitative structure toxicity relationship models for mice via the oral LD50 model and the S. typhimurium (TA98 + S9) mutagenic model of halogenated benzenes were developed using multiple linear regression (MLR) analysis. The validation results obtained from the test set indicate that the proposed models are robust and satisfactory. |
| 资助信息 | Ministry of Environmental Protection of China [2011467037] |
| 语种 | 英语 |
| 公开日期 | 2015-04-14 |
| 源URL | [http://ir.iphy.ac.cn/handle/311004/58937]  |
| 专题 | 物理研究所_物理所公开发表论文_物理所公开发表论文_期刊论文 |
| 推荐引用方式 GB/T 7714 | Zhang, XL,Zhou, ZX,Fan, XL,et al. QSTR Studies on Acute Toxicity and Mutagenicity of Halogenated Benzenes[J]. ASIAN JOURNAL OF CHEMISTRY,2014,26(9):2707. |
| APA | Zhang, XL,Zhou, ZX,Fan, XL,Liu, YH,Li, HD,&Wang, JT.(2014).QSTR Studies on Acute Toxicity and Mutagenicity of Halogenated Benzenes.ASIAN JOURNAL OF CHEMISTRY,26(9),2707. |
| MLA | Zhang, XL,et al."QSTR Studies on Acute Toxicity and Mutagenicity of Halogenated Benzenes".ASIAN JOURNAL OF CHEMISTRY 26.9(2014):2707. |
入库方式： OAI收割
来源：物理研究所
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