Effects of pH on Oxaliplatin-Induced Condensation of Single DNA Molecules
文献类型：期刊论文
| 作者 | Zhang, HY ; Ji, C ; Liu, YR ; Li, W ; Li, H ; Dou, SX ; Wang, WC ; Zhang, LY ; Xie, P ; Wang, PY |
| 刊名 | CHINESE PHYSICS LETTERS
 |
| 出版日期 | 2014 |
| 卷号 | 31期号:2 |
| ISSN号 | 0256-307X |
| 通讯作者 | Wang, PY (reprint author), Chinese Acad Sci, Inst Phys, Beijing Natl Lab Condensed Matter Phys, Key Lab Soft Matter Phys, Beijing 100190, Peoples R China. |
| 中文摘要 | By using magnetic tweezers, atomic force microscope and mass spectrometry, we study the effects of pH on oxaliplatin-induced DNA condensation, the DNA persistence length, the amounts of micro-loops and of oxaliplatin bound to DNA. It is found that the DNA condensation degree, the amounts of micro-loops and of oxaliplatin bound to DNA increase with the decrease in the pH value while the DNA persistence length has an opposite behavior. The observed effects may be related to the drug resistance of cancer cells. |
| 资助信息 | National Natural Science Foundation of China [11274374, 11104341, 31070751]; National Basic Research Program of China [2013CB837200] |
| 语种 | 英语 |
| 公开日期 | 2015-04-14 |
| 源URL | [http://ir.iphy.ac.cn/handle/311004/59039]  |
| 专题 | 物理研究所_物理所公开发表论文_物理所公开发表论文_期刊论文 |
| 推荐引用方式 GB/T 7714 | Zhang, HY,Ji, C,Liu, YR,et al. Effects of pH on Oxaliplatin-Induced Condensation of Single DNA Molecules[J]. CHINESE PHYSICS LETTERS,2014,31(2). |
| APA | Zhang, HY.,Ji, C.,Liu, YR.,Li, W.,Li, H.,...&Wang, PY.(2014).Effects of pH on Oxaliplatin-Induced Condensation of Single DNA Molecules.CHINESE PHYSICS LETTERS,31(2). |
| MLA | Zhang, HY,et al."Effects of pH on Oxaliplatin-Induced Condensation of Single DNA Molecules".CHINESE PHYSICS LETTERS 31.2(2014). |
入库方式： OAI收割
来源：物理研究所
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