Local conformation transitions of linear DNA induced by cisplatin
文献类型：期刊论文
| 作者 | Ji, C ; Zhang, LY ; Dou, SX ; Wang, PY |
| 刊名 | CHINESE SCIENCE BULLETIN
 |
| 出版日期 | 2014 |
| 卷号 | 59期号:25页码:3085 |
| ISSN号 | 1001-6538 |
| 关键词 | Atomic force microscopy Cisplatin DNA Conformation transition |
| 通讯作者 | Wang, PY (reprint author), Chinese Acad Sci, Inst Phys, Beijing Natl Lab Condensed Matter Phys, Key Lab Soft Matter Phys, Beijing 100190, Peoples R China. |
| 中文摘要 | Cisplatin is the most successful anti-tumor drug, and its pharmacological property is generally considered to derive from the modification of DNA molecules. Structural modifications of short DNA induced by cisplatin have already been investigated. However, the conformation transitions induced by cisplatin are not clear. In the present letter, we have studied the effect of low-concentration cisplatin on DNA conformation by using AFM imaging. We observed formations of micro-rod structures of linear DNA induced by cisplatin. A method is presented to quantitatively analyze the occurrence of micro-rod structures. We found that the formation of micro-rod structures depends on the DNA sequence. Based on the results, we proposed a physical mechanism to explain the local conformation transitions of DNA molecules under the influence of cisplatin. |
| 资助信息 | National Natural Science Foundation of China [11274374]; National Basic Research Program of China [2009CB930704] |
| 语种 | 英语 |
| 公开日期 | 2015-04-14 |
| 源URL | [http://ir.iphy.ac.cn/handle/311004/59046]  |
| 专题 | 物理研究所_物理所公开发表论文_物理所公开发表论文_期刊论文 |
| 推荐引用方式 GB/T 7714 | Ji, C,Zhang, LY,Dou, SX,et al. Local conformation transitions of linear DNA induced by cisplatin[J]. CHINESE SCIENCE BULLETIN,2014,59(25):3085. |
| APA | Ji, C,Zhang, LY,Dou, SX,&Wang, PY.(2014).Local conformation transitions of linear DNA induced by cisplatin.CHINESE SCIENCE BULLETIN,59(25),3085. |
| MLA | Ji, C,et al."Local conformation transitions of linear DNA induced by cisplatin".CHINESE SCIENCE BULLETIN 59.25(2014):3085. |
入库方式： OAI收割
来源：物理研究所
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