Dynamics of+1 ribosomal frameshifting
文献类型：期刊论文
| 作者 | Xie, P |
| 刊名 | MATHEMATICAL BIOSCIENCES
 |
| 出版日期 | 2014 |
| 卷号 | 249页码:44 |
| 关键词 | Ribosome Translational regulation Ribosome pausing Translation elongation Virus |
| ISSN号 | 0025-5564 |
| 通讯作者 | Xie, P (reprint author), Chinese Acad Sci, Key Lab Soft Matter Phys, Inst Phys, Beijing 100190, Peoples R China. |
| 中文摘要 | It has been well characterized that the amino acid starvation can induce +1 frameshifting. However, how the +1 frameshifting occurs has not been fully understood. Here, taking Escherichia coli RF2 programmed frameshifting as an example we present systematical analysis of the +1 frameshifting that could occur during every state-transition step in elongation phase of protein synthesis, showing that the +1 frameshifting can occur only during the period after deacylated tRNA dissociation from the posttranslocation state and before the recognition of the next "hungry" codon. The +1 frameshifting efficiency is theoretically studied, with the simple analytical solutions showing that the high efficiency is almost solely due to the occurrence of ribosome pausing which in turn results from the insufficient RF2. The analytical solutions also provide a consistent explanation of a lot of independent experimental data. (C) 2014 Elsevier Inc. All rights reserved. |
| 资助信息 | National Natural Science Foundation of China [11374352] |
| 语种 | 英语 |
| 公开日期 | 2015-04-14 |
| 源URL | [http://ir.iphy.ac.cn/handle/311004/59321]  |
| 专题 | 物理研究所_物理所公开发表论文_物理所公开发表论文_期刊论文 |
| 推荐引用方式 GB/T 7714 | Xie, P. Dynamics of+1 ribosomal frameshifting[J]. MATHEMATICAL BIOSCIENCES,2014,249:44. |
| APA | Xie, P.(2014).Dynamics of+1 ribosomal frameshifting.MATHEMATICAL BIOSCIENCES,249,44. |
| MLA | Xie, P."Dynamics of+1 ribosomal frameshifting".MATHEMATICAL BIOSCIENCES 249(2014):44. |
入库方式： OAI收割
来源：物理研究所
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