Dynamic MRI of rat brain following manganese administration through the internal carotid artery
文献类型：期刊论文
| 作者 | Zhang, R ; Fa, ZQ ; Liu, Y ; Sun, HT ; Li, P ; Li, SR ; Wang, XX ; Lei, H ; Jiang, XD |
| 刊名 | NEUROLOGICAL RESEARCH
 |
| 出版日期 | 2014 |
| 卷号 | 36期号:7页码:679 |
| 关键词 | Dynamic MRI Manganese Blood-brain barrier (BBB) Internal carotid artery (ICA) |
| ISSN号 | 0161-6412 |
| 通讯作者 | Jiang, XD (reprint author), Southern Med Univ, Neurosurg Inst Guangdong, Zhujiang Hosp, Guangzhou 510282, Guangdong, Peoples R China. |
| 中文摘要 | Objective: In this study, we investigated the dynamic distribution processes of Mn2+ in rat brain using magnetic resonance imaging (MRI) after an intra-arterial (IA) injection of MnCl2 and following the breaking of the blood-brain barrier (BBB). Methods: Adult male Sprague-Dawley (SD) rats were employed in the study. After the rats were anesthetized with urethane, 25% mannitol was administrated into the right internal carotid artery (ICA) in order to disrupt the BBB, 50 mmol/l (10 mg/kg) of MnCl2 was then injected into ICA prior to the MRI assay. The MRI was performed at 7 T for a continuous 2 hours following the administration of MnCl2. Image reconstruction and analysis were performed using the Statistical Parametric Mapping (SPM) software. Results: As time progressed, the Mn2+ enhanced signal intensity showed a gradual increase with a maximum increase at 10 minutes following MnCl2 administration, and began to decline after 10 minutes. From 30 minutes to 2 hours, the signal-enhanced region became more homogeneous, and the signalenhanced range spread to the contralateral area up to 2 hours after MnCl2 administration. Conclusion: These results will help future research to select an appropriate time point to perform functional MRI for different types of activity-induced manganese (AIM) MRI research studies. These findings will allow researchers to discriminate intended, stimulation-specific enhanced signal from unintended, nonspecific enhanced signals. |
| 资助信息 | National Science Fund of China [81171179, 81272439, 31300921]; Funds for Key Sci-Tech Research Projects of Guangdong [2008A030201019]; Guangzhou [09B52120112-2009J1-C418-2, 2008A1-E4011-6] |
| 语种 | 英语 |
| 公开日期 | 2015-04-14 |
| 源URL | [http://ir.iphy.ac.cn/handle/311004/59397]  |
| 专题 | 物理研究所_物理所公开发表论文_物理所公开发表论文_期刊论文 |
| 推荐引用方式 GB/T 7714 | Zhang, R,Fa, ZQ,Liu, Y,et al. Dynamic MRI of rat brain following manganese administration through the internal carotid artery[J]. NEUROLOGICAL RESEARCH,2014,36(7):679. |
| APA | Zhang, R.,Fa, ZQ.,Liu, Y.,Sun, HT.,Li, P.,...&Jiang, XD.(2014).Dynamic MRI of rat brain following manganese administration through the internal carotid artery.NEUROLOGICAL RESEARCH,36(7),679. |
| MLA | Zhang, R,et al."Dynamic MRI of rat brain following manganese administration through the internal carotid artery".NEUROLOGICAL RESEARCH 36.7(2014):679. |
入库方式： OAI收割
来源：物理研究所
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