Effects of oxaliplatin on DNA condensation
文献类型：期刊论文
| 作者 | Ju, HP ; Zhang, HY ; Li, W ; Wang, PY |
| 刊名 | SCIENCE CHINA-PHYSICS MECHANICS & ASTRONOMY
 |
| 出版日期 | 2014 |
| 卷号 | 57期号:11页码:2114 |
| 关键词 | oxaliplatin transplatin DNA condensation magnetic tweezers |
| ISSN号 | 1674-7348 |
| 通讯作者 | Li, W (reprint author), Chinese Acad Sci, Beijing Natl Lab Condensed Matter Phys, Beijing 100190, Peoples R China. |
| 中文摘要 | In this paper the interactions between DNA and anti-cancer drug oxaliplatin were investigated by using magnetic tweezers. The dynamics of DNA condensation due to oxaliplatin was traced under various forces. It is found that torsion constraint in DNA enhances the ability of oxaliplatin for shortening DNA. The transplatin helps oxaliplatin combine to DNA and increase the rate of DNA condensation. All these results are consistent to the previously proposed model and are helpful for further investigation of interaction between DNA and oxaliplatin. |
| 资助信息 | National Natural Science Foundation of China [11104341, 11274374]; National Basic Research Program of China [2013CB837200] |
| 语种 | 英语 |
| 公开日期 | 2015-04-14 |
| 源URL | [http://ir.iphy.ac.cn/handle/311004/59663]  |
| 专题 | 物理研究所_物理所公开发表论文_物理所公开发表论文_期刊论文 |
| 推荐引用方式 GB/T 7714 | Ju, HP,Zhang, HY,Li, W,et al. Effects of oxaliplatin on DNA condensation[J]. SCIENCE CHINA-PHYSICS MECHANICS & ASTRONOMY,2014,57(11):2114. |
| APA | Ju, HP,Zhang, HY,Li, W,&Wang, PY.(2014).Effects of oxaliplatin on DNA condensation.SCIENCE CHINA-PHYSICS MECHANICS & ASTRONOMY,57(11),2114. |
| MLA | Ju, HP,et al."Effects of oxaliplatin on DNA condensation".SCIENCE CHINA-PHYSICS MECHANICS & ASTRONOMY 57.11(2014):2114. |
入库方式： OAI收割
来源：物理研究所
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