The linear interplay of intrinsic and extrinsic noises ensures a high accuracy of cell fate selection in budding yeast
文献类型：期刊论文
| 作者 | Li, YK ; Yi, M ; Zou, XF |
| 刊名 | SCIENTIFIC REPORTS
 |
| 出版日期 | 2014 |
| 卷号 | 4 |
| ISSN号 | 2045-2322 |
| 通讯作者 | Yi, M (reprint author), Chinese Acad Sci, Wuhan Inst Phys & Math, Key Lab Magnet Resonance Biol Syst, Beijing, Peoples R China. |
| 中文摘要 | To gain insights into the mechanisms of cell fate decision in a noisy environment, the effects of intrinsic and extrinsic noises on cell fate are explored at the single cell level. Specifically, we theoretically define the impulse of Cln1/2 as an indication of cell fates. The strong dependence between the impulse of Cln1/2 and cell fates is exhibited. Based on the simulation results, we illustrate that increasing intrinsic fluctuations causes the parallel shift of the separation ratio of Whi5P but that increasing extrinsic fluctuations leads to the mixture of different cell fates. Our quantitative study also suggests that the strengths of intrinsic and extrinsic noises around an approximate linear model can ensure a high accuracy of cell fate selection. Furthermore, this study demonstrates that the selection of cell fates is an entropy-decreasing process. In addition, we reveal that cell fates are significantly correlated with the range of entropy decreases. |
| 资助信息 | Major Research Plan of the National Natural Science Foundation of China [91230118, 91330113]; National Natural Science Foundation of China [11275259, 61173060] |
| 语种 | 英语 |
| 公开日期 | 2015-04-14 |
| 源URL | [http://ir.iphy.ac.cn/handle/311004/59707]  |
| 专题 | 物理研究所_物理所公开发表论文_物理所公开发表论文_期刊论文 |
| 推荐引用方式 GB/T 7714 | Li, YK,Yi, M,Zou, XF. The linear interplay of intrinsic and extrinsic noises ensures a high accuracy of cell fate selection in budding yeast[J]. SCIENTIFIC REPORTS,2014,4. |
| APA | Li, YK,Yi, M,&Zou, XF.(2014).The linear interplay of intrinsic and extrinsic noises ensures a high accuracy of cell fate selection in budding yeast.SCIENTIFIC REPORTS,4. |
| MLA | Li, YK,et al."The linear interplay of intrinsic and extrinsic noises ensures a high accuracy of cell fate selection in budding yeast".SCIENTIFIC REPORTS 4(2014). |
入库方式： OAI收割
来源：物理研究所
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