Pneumatic-pumping metering in CD-like microfluidic chip for whole blood analysis
文献类型：期刊论文
| 作者 | Deng Y.-B. ; Wu Y.-H.; Liu Y.-S.; Wu J.-F.
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| 刊名 | Guangxue Jingmi Gongcheng/Optics and Precision Engineering
 |
| 出版日期 | 2014 |
| 卷号 | 22期号:10页码:2733-2739 |
| ISSN号 | ISBN/1004924X |
| 英文摘要 | To overcome the dependence of the plasma extraction on siphon hydrophilicity in a centrifugal microfluidic chip and to ensure long-term stability and reliability of the microfluidic chip, a compressed air reservoir connected to the blood separated reservoir was proposed to separate the blood in blood separated reservoir at high rotating speeds. Through lowering the spinning speed, the plasma in the separated reservoir was pumped toward the CD-like chip center to release the stored air pressure produced by the rotation at high spinning speeds. Based on the thermodynamics of the isothermal gas, the pneumatic pumping method was modeled, and the model was confirmed by analyzing pumping positions and air compression versus spinning speeds. By using the layered Polymethyl Methacrylate(PMMA)as materials, the centrifugal microfluidic chips for plasma extraction were fabricated with a CO2 laser process technique and the volume of compressed air and the blood position at siphon were tested at different rotational speeds. Experimental results demonstrate that the achieved volume of compression is 8.7L and the siphon valve effectively inhibits whole blood to overflow the crest of siphon at 4 000 r/min speed. With lowering the spin speed to 1 000 r/min, the release of compressed air overcomes the centrifugal force and drives the plasma to flow past the crest of siphon. Then the plasma extraction is realized in quantitation. |
| 收录类别 | EI |
| 语种 | 中文 |
| 源URL | [http://ir.ciomp.ac.cn/handle/181722/44274]  |
| 专题 | 长春光学精密机械与物理研究所_中科院长春光机所知识产出 |
| 推荐引用方式 GB/T 7714 | Deng Y.-B.,Wu Y.-H.,Liu Y.-S.,et al. Pneumatic-pumping metering in CD-like microfluidic chip for whole blood analysis[J]. Guangxue Jingmi Gongcheng/Optics and Precision Engineering,2014,22(10):2733-2739. |
| APA | Deng Y.-B.,Wu Y.-H.,Liu Y.-S.,&Wu J.-F..(2014).Pneumatic-pumping metering in CD-like microfluidic chip for whole blood analysis.Guangxue Jingmi Gongcheng/Optics and Precision Engineering,22(10),2733-2739. |
| MLA | Deng Y.-B.,et al."Pneumatic-pumping metering in CD-like microfluidic chip for whole blood analysis".Guangxue Jingmi Gongcheng/Optics and Precision Engineering 22.10(2014):2733-2739. |
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