Complex Evolutionary Patterns Revealed by Mitochondrial Genomes of the Domestic Horse
文献类型：期刊论文
| 作者 | Ning, T ; Li, J ; Lin, K ; Xiao, H ; Wylie, S ; Hua, S ; Li, H ; Zhang, YP |
| 刊名 | CURRENT MOLECULAR MEDICINE
 |
| 出版日期 | 2014 |
| 卷号 | 14期号:10页码:1286-1298 |
| 关键词 | CYTOCHROME-C-OXIDASE AMINO-ACID SITES MAXIMUM-LIKELIHOOD-ESTIMATION ADAPTIVE EVOLUTION PATERNAL INHERITANCE NONNEUTRAL EVOLUTION POSITIVE SELECTION SUBSTITUTION RATES NATURAL-SELECTION ACCELERATED EVOLUTION |
| ISSN号 | 1566-5240 |
| 中文摘要 | The domestic horse is the most widely used and important stock and recreational animal, valued for its strength and endurance. The energy required by the domestic horse is mainly supplied by mitochondria via oxidative phosphorylation. Thus, selection may have played an essential role in the evolution of the horse mitochondria. Besides, demographic events also affect the DNA polymorphic pattern on mitochondria. To understand the evolutionary patterns of the mitochondria of the domestic horse, we used a deep sequencing approach to obtain the complete sequences of 15 mitochondrial genomes, and four mitochondrial gene sequences, ND6, ATP8, ATP6 and CYTB, collected from 509, 363, 363 and 409 domestic horses, respectively. Evidence of strong substitution rate heterogeneity was found at nonsynonymous sites across the genomes. Signatures of recent positive selection on mtDNA of domestic horse were detected. Specifically, five amino acids in the four mitochondrial genes were identified as the targets of positive selection. Coalescent-based simulations imply that recent population expansion is the most probable explanation for the matrilineal population history for domestic horse. Our findings reveal a complex pattern of non-neutral evolution of the mitochondrial genome in the domestic horses. |
| 语种 | 英语 |
| 公开日期 | 2015-03-26 |
| 源URL | [http://ir.xtbg.org.cn/handle/353005/8394]  |
| 专题 | 西双版纳热带植物园_其他 |
| 推荐引用方式 GB/T 7714 | Ning, T,Li, J,Lin, K,et al. Complex Evolutionary Patterns Revealed by Mitochondrial Genomes of the Domestic Horse[J]. CURRENT MOLECULAR MEDICINE,2014,14(10):1286-1298. |
| APA | Ning, T.,Li, J.,Lin, K.,Xiao, H.,Wylie, S.,...&Zhang, YP.(2014).Complex Evolutionary Patterns Revealed by Mitochondrial Genomes of the Domestic Horse.CURRENT MOLECULAR MEDICINE,14(10),1286-1298. |
| MLA | Ning, T,et al."Complex Evolutionary Patterns Revealed by Mitochondrial Genomes of the Domestic Horse".CURRENT MOLECULAR MEDICINE 14.10(2014):1286-1298. |
入库方式： OAI收割
来源：西双版纳热带植物园
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