Functional Characterization of MpaG ', the O-Methyltransferase Involved in the Biosynthesis of Mycophenolic Acid
文献类型：期刊论文
| 作者 | Liu, CN
|
| 刊名 | CHEMBIOCHEM
 |
| 出版日期 | 2015 |
| 卷号 | 16期号:4页码:565-569 |
| 关键词 | biosynthesis methyltransferases mycophenolic acid substrate flexibility transferases |
| ISSN号 | 1439-4227 |
| 中文摘要 | Mycophenolic acid (MPA, 1) is a clinically important immunosuppressant. In this report, a gene cluster mpa responsible for the biosynthesis of 1 was identified from Penicillium brevicompactum NRRL 864. The S-adenosyl-L-methionine-dependent (SAM-dependent) O-methyltransferase encoded by the mpaG gene was functionally and kinetically characterized in vitro. MpaG catalyzes the methylation of demethylmycophenolic acid (DMMPA, 6) to form 1. It also showed significant substrate flexibility by methylating two structural derivatives of 6 prepared by organic synthesis. |
| 原文出处 | 10.1002/cbic.201402600 |
| 公开日期 | 2015-04-28 |
| 源URL | [http://ir.xtbg.org.cn/handle/353005/8682]  |
| 专题 | 西双版纳热带植物园_其他 西双版纳热带植物园_2012年后新成立研究组 |
| 推荐引用方式 GB/T 7714 | Liu, CN. Functional Characterization of MpaG ', the O-Methyltransferase Involved in the Biosynthesis of Mycophenolic Acid[J]. CHEMBIOCHEM,2015,16(4):565-569. |
| APA | Liu, CN.(2015).Functional Characterization of MpaG ', the O-Methyltransferase Involved in the Biosynthesis of Mycophenolic Acid.CHEMBIOCHEM,16(4),565-569. |
| MLA | Liu, CN."Functional Characterization of MpaG ', the O-Methyltransferase Involved in the Biosynthesis of Mycophenolic Acid".CHEMBIOCHEM 16.4(2015):565-569. |
入库方式： OAI收割
来源：西双版纳热带植物园
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