beta-CATENIN IS REQUIRED FOR MAINTAINING HIPPOCAMPAL MORPHOLOGY DURING THE PERINATAL PERIOD
文献类型：期刊论文
| 作者 | Wang, H. -T. ; Zeng, L. ; Chen, Q. ; Zhang, X. ; Liu, J. -W. ; Lu, T. -J. ; Xiong, Z. -Q. ; Zheng, J. ; Hu, Z. -L. |
| 刊名 | NEUROSCIENCE
 |
| 出版日期 | 2015 |
| 卷号 | 284页码:273-282 |
| 关键词 | RADIAL GLIAL SCAFFOLD DENTATE GYRUS MOUSE BRAIN MORPHOGENESIS REELIN ABNORMALITIES EXPRESSION MOLECULES MIGRATION |
| 通讯作者 | Zheng, J (reprint author), E China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab New Drug Design, Shanghai 200237, Peoples R China. |
| 英文摘要 | In mice, the compact hippocampal primordium is formed during the prenatal stage by early-generated neurons that migrate from the lateral ventricular zone. However, despite much being understood about the formation of the hippocampus, the molecular mechanisms that maintain the morphology of the hippocampal primordium after its formation remain to be characterized. beta-Catenin is a key factor of canonical Wnt signaling and also a component of adherens junctions. Previous embryonic deletion studies have demonstrated that beta-catenin is required for early development and generation of granule cells. However, whether beta-catenin is involved in the morphological maintenance of the hippocampus as a cell adhesion molecule is still unknown. Here, we report that perinatal deletion of beta-catenin in postmitotic neurons and some radial glial cells of hippocampus using CamKII alpha-iCre; beta-catenin(flox/flox) conditional knockout mice, leads to disorganization of the radial glial scaffold and consequentially severe defects in hippocampal morphology. We demonstrate that beta-catenin is required for maintaining radial glial scaffold possibly via its well-known role in cell adhesion during the perinatal period. These findings provide essential advances into our understanding of the maintenance of the hippocampal primordium during the perinatal period. (C) 2014 IBRO. Published by Elsevier Ltd. All rights reserved. |
| WOS标题词 | Neurosciences & Neurology |
| 学科主题 | Neurosciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000346243100025 |
| 公开日期 | 2015-05-27 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/2665]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Wang, H. -T.,Zeng, L.,Chen, Q.,et al. beta-CATENIN IS REQUIRED FOR MAINTAINING HIPPOCAMPAL MORPHOLOGY DURING THE PERINATAL PERIOD[J]. NEUROSCIENCE,2015,284:273-282. |
| APA | Wang, H. -T..,Zeng, L..,Chen, Q..,Zhang, X..,Liu, J. -W..,...&Hu, Z. -L..(2015).beta-CATENIN IS REQUIRED FOR MAINTAINING HIPPOCAMPAL MORPHOLOGY DURING THE PERINATAL PERIOD.NEUROSCIENCE,284,273-282. |
| MLA | Wang, H. -T.,et al."beta-CATENIN IS REQUIRED FOR MAINTAINING HIPPOCAMPAL MORPHOLOGY DURING THE PERINATAL PERIOD".NEUROSCIENCE 284(2015):273-282. |
入库方式： OAI收割
来源：上海神经科学研究所
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