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Enriched Environment Inhibits Mouse Pancreatic Cancer Growth and Down-regulates the Expression of Mitochondria-related Genes in Cancer Cells
文献类型：期刊论文
| 作者 | Li, Guohua ; Gan, Yu ; Fan, Yingchao ; Wu, Yufeng ; Lin, Hechun ; Song, Yanfang ; Cai, Xiaojin ; Yu, Xiang ; Pan, Weihong ; Yao, Ming ; Gu, Jianren ; Tu, Hong |
| 刊名 | SCIENTIFIC REPORTS
 |
| 出版日期 | 2015 |
| 卷号 | 5页码:7856-7856 |
| 关键词 | NEURODEGENERATIVE DISEASES PSYCHOSOCIAL FACTORS STRESS RESPONSES MICE DYSFUNCTION METABOLISM CARCINOMA WARBURG ANXIETY AXIS |
| 通讯作者 | Tu, H (reprint author), Shanghai Jiao Tong Univ, Sch Med, Shanghai Canc Inst, State Key Lab Oncogenes & Related Genes,Renji Hos, 25 Ln 2200 Xietu Rd, Shanghai 200032, Peoples R China. |
| 英文摘要 | Psycho-social stress has been suggested to influence the development of cancer, but it remains poorly defined with regard to pancreatic cancer, a lethal malignancy with few effective treatment modalities. In this study, we sought to investigate the impacts of enriched environment (EE) housing, a rodent model of "eustress'', on the growth of mouse pancreatic cancer, and to explore the potential underlying mechanisms through gene expression profiling. The EE mice showed significantly reduced tumor weights in both subcutaneous (53%) and orthotopic (41%) models, while each single component of EE (inanimate stimulation, social stimulation or physical exercise) was not profound enough to achieve comparative anti-tumor effects as EE. The integrative transcriptomic and proteomic analysis revealed that in response to EE, a total of 129 genes in the tumors showed differential expression at both the mRNA and protein levels. The differentially expressed genes were mostly localized to the mitochondria and enriched in the citrate cycle and oxidative phosphorylation pathways. Interestingly, nearly all of the mitochondria-related genes were down-regulated by EE. Our data have provided experimental evidence in favor of the application of positive stress or of benign environmental stimulation in pancreatic cancer therapy. |
| WOS标题词 | Science & Technology - Other Topics |
| 学科主题 | Multidisciplinary Sciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000347978300017 |
| 公开日期 | 2015-05-27 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/2667]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Li, Guohua,Gan, Yu,Fan, Yingchao,et al. Enriched Environment Inhibits Mouse Pancreatic Cancer Growth and Down-regulates the Expression of Mitochondria-related Genes in Cancer Cells[J]. SCIENTIFIC REPORTS,2015,5:7856-7856. |
| APA | Li, Guohua.,Gan, Yu.,Fan, Yingchao.,Wu, Yufeng.,Lin, Hechun.,...&Tu, Hong.(2015).Enriched Environment Inhibits Mouse Pancreatic Cancer Growth and Down-regulates the Expression of Mitochondria-related Genes in Cancer Cells.SCIENTIFIC REPORTS,5,7856-7856. |
| MLA | Li, Guohua,et al."Enriched Environment Inhibits Mouse Pancreatic Cancer Growth and Down-regulates the Expression of Mitochondria-related Genes in Cancer Cells".SCIENTIFIC REPORTS 5(2015):7856-7856. |
入库方式： OAI收割
来源：上海神经科学研究所
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