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Tet1-mediated DNA demethylation regulates neuronal cell death induced by oxidative stress
文献类型：期刊论文
| 作者 | Xin, Yong-Juan ; Yuan, Bo ; Yu, Bin ; Wang, Yu-Qing ; Wu, Jia-Jia ; Zhou, Wen-Hao ; Qiu, Zilong |
| 刊名 | SCIENTIFIC REPORTS
 |
| 出版日期 | 2015 |
| 卷号 | 5页码:7645-7645 |
| 关键词 | TET1 METHYLATION BRAIN EXPRESSION APOPTOSIS PATHWAY DISEASE |
| 通讯作者 | Qiu, ZL (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, CAS Ctr Excellence Brain Sci, Inst Neurosci,Key Lab Primate Neurobiol, Shanghai 200031, Peoples R China. |
| 英文摘要 | Epigenetic regulations including DNA methylation and demethylation play critical roles in neural development. However, whether DNA methylation and demethylation may play a role in neuronal cell death remains largely unclear. Here we report that the blockade of DNA methyltransferase inhibits apoptosis of cerebellar granule cells and cortical neurons in response to oxidative stress. We found that knockdown of ten-eleven translocation methylcytosine dioxygenase (Tet1), a critical enzyme for DNA demethylation, significantly increase apoptosis of cerebellar granule cells induced by hydrogen peroxide. Moreover, cerebellar granule cells from tet1(null) mice appeared to be more sensitive to oxidative stress, suggesting the critical role of Tet1 in neuronal cell death. We further showed that the expression of Klotho, an antiaging protein, in cerebellar granule cells is tightly regulated by DNA methylation. Finally, we found that knockdown of Klotho diminished the rescue effects of DNA methyltransferase inhibitors and Tet1 on neuronal cell death induced by oxidative stress. Our work revealed the role of Tet1-mediated DNA demethylation on neuronal protection against oxidative stress and provided the molecular mechanisms underlying the epigenetic regulation of neuronal cell death, suggesting the role of Klotho in regulating neuronal cell death in response to oxidative stress. |
| WOS标题词 | Science & Technology - Other Topics |
| 学科主题 | Multidisciplinary Sciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000347796200011 |
| 公开日期 | 2015-05-27 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/2670]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Xin, Yong-Juan,Yuan, Bo,Yu, Bin,et al. Tet1-mediated DNA demethylation regulates neuronal cell death induced by oxidative stress[J]. SCIENTIFIC REPORTS,2015,5:7645-7645. |
| APA | Xin, Yong-Juan.,Yuan, Bo.,Yu, Bin.,Wang, Yu-Qing.,Wu, Jia-Jia.,...&Qiu, Zilong.(2015).Tet1-mediated DNA demethylation regulates neuronal cell death induced by oxidative stress.SCIENTIFIC REPORTS,5,7645-7645. |
| MLA | Xin, Yong-Juan,et al."Tet1-mediated DNA demethylation regulates neuronal cell death induced by oxidative stress".SCIENTIFIC REPORTS 5(2015):7645-7645. |
入库方式： OAI收割
来源：上海神经科学研究所
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