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Beneficial synergistic effects of microdose lithium with pyrroloquinoline quinone in an Alzheimer's disease mouse model
文献类型：期刊论文
| 作者 | Zhao, Lei; Gong, Neng; Liu, Meng; Pan, Xiaoli; Sang, Shaoming; Sun, Xiaojing; Yu, Zhe; Fang, Qi; Zhao, Na; Fei, Guoqiang |
| 刊名 | NEUROBIOLOGY OF AGING
 |
| 出版日期 | 2014 |
| 卷号 | 35期号:12页码:2736-2745 |
| 关键词 | A-BETA COGNITIVE IMPAIRMENT TAU PHOSPHORYLATION HYPOTHESIS DEMENTIA INHIBITION PATHWAY TRIAL RISK |
| 通讯作者 | Zhong, CJ (reprint author), Fudan Univ, Zhongshan Hosp, Dept Neurol, Shanghai 200032, Peoples R China. |
| 英文摘要 | Alzheimer's disease (AD) is a complicated, neurodegenerative disorder involving multifactorial pathogeneses and still lacks effective clinical treatment. Recent studies show that lithium exerts disease-modifying effects against AD. However, the intolerant side effects at conventional effective dosage limit the clinical use of lithium in treating AD. To explore a novel AD treatment strategy with microdose lithium, we designed and synthesized a new chemical, tri-lithium pyrroloquinoline quinone (Li(3)PQQ), to study the synergistic effects of low-dose lithium and pyrroloquinoline quinone, a native compound with powerful antioxidation and mitochondrial amelioration. The results showed that Li(3)PQQ at a relative low dose (6 and 12 mg/kg) exhibited more powerful effects in restoring the impairment of learning and memory, facilitating hippocampal long-term potentiation, and reducing cerebral amyloid deposition and phosphorylated tau level in APP/PS1 transgenic mice than that of lithium chloride at both low and high dose (5 and 100 mg/kg). We further found that Li(3)PQQ inhibited the activity of glycogen synthase kinase-3 and increased the activity of beta-amyloid-binding alcohol dehydrogenase, which might underlie the beneficial effects of Li(3)PQQ on APP/PS1 transgenic mice. Our study demonstrated the efficacy of a novel AD therapeutic strategy targeting at multiple disease-causing mechanisms through the synergistic effects of microdose lithium and pyrroloquinoline quinone. (C) 2014 Elsevier Inc. All rights reserved. |
| WOS标题词 | Geriatrics & Gerontology ; Neurosciences & Neurology |
| 学科主题 | Geriatrics & Gerontology ; Neurosciences |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000347233200009 |
| 公开日期 | 2015-05-27 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/2676]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Zhao, Lei,Gong, Neng,Liu, Meng,et al. Beneficial synergistic effects of microdose lithium with pyrroloquinoline quinone in an Alzheimer's disease mouse model[J]. NEUROBIOLOGY OF AGING,2014,35(12):2736-2745. |
| APA | Zhao, Lei.,Gong, Neng.,Liu, Meng.,Pan, Xiaoli.,Sang, Shaoming.,...&Xu, Tianle.(2014).Beneficial synergistic effects of microdose lithium with pyrroloquinoline quinone in an Alzheimer's disease mouse model.NEUROBIOLOGY OF AGING,35(12),2736-2745. |
| MLA | Zhao, Lei,et al."Beneficial synergistic effects of microdose lithium with pyrroloquinoline quinone in an Alzheimer's disease mouse model".NEUROBIOLOGY OF AGING 35.12(2014):2736-2745. |
入库方式： OAI收割
来源：上海神经科学研究所
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