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Activated astrocytes enhance the dopaminergic differentiation of stem cells and promote brain repair through bFGF
文献类型：期刊论文
| 作者 | Yang, Fan ; Liu, Yunhui ; Tu, Jie ; Wan, Jun ; Zhang, Jie ; Wu, Bifeng ; Chen, Shanping ; Zhou, Jiawei ; Mu, Yangling ; Wang, Liping |
| 刊名 | NATURE COMMUNICATIONS
 |
| 出版日期 | 2014 |
| 卷号 | 5页码:5627-5627 |
| 关键词 | FIBROBLAST-GROWTH-FACTOR MODULATES FGF-2 EXPRESSION NEURONS IN-VIVO PARKINSONS-DISEASE SUBSTANTIA-NIGRA NEURAL SPECIFICATION DEPENDENT RELEASE SCHWANN-CELLS MOUSE MODEL RAT MODEL |
| 通讯作者 | Wang, LP (reprint author), Chinese Acad Sci, Shenzhen Inst Adv Technol, Shenzhen Key Lab Neuropsychiat Modulat, CAS Ctr Excellence Brain Sci, Shenzhen 518055, Peoples R China. |
| 英文摘要 | Astrocytes provide neuroprotective effects against degeneration of dopaminergic (DA) neurons and play a fundamental role in DA differentiation of neural stem cells. Here we show that light illumination of astrocytes expressing engineered channelrhodopsin variant (ChETA) can remarkably enhance the release of basic fibroblast growth factor (bFGF) and significantly promote the DA differentiation of human embryonic stem cells (hESCs) in vitro. Light activation of transplanted astrocytes in the substantia nigra (SN) also upregulates bFGF levels in vivo and promotes the regenerative effects of co-transplanted stem cells. Importantly, upregulation of bFGF levels, by specific light activation of endogenous astrocytes in the SN, enhances the DA differentiation of transplanted stem cells and promotes brain repair in a mouse model of Parkinson's disease (PD). Our study indicates that astrocyte-derived bFGF is required for regulation of DA differentiation of the stem cells and may provide a strategy targeting astrocytes for treatment of PD. |
| WOS标题词 | Science & Technology - Other Topics |
| 学科主题 | Multidisciplinary Sciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000347226400001 |
| 公开日期 | 2015-05-27 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/2677]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Yang, Fan,Liu, Yunhui,Tu, Jie,et al. Activated astrocytes enhance the dopaminergic differentiation of stem cells and promote brain repair through bFGF[J]. NATURE COMMUNICATIONS,2014,5:5627-5627. |
| APA | Yang, Fan.,Liu, Yunhui.,Tu, Jie.,Wan, Jun.,Zhang, Jie.,...&Wang, Liping.(2014).Activated astrocytes enhance the dopaminergic differentiation of stem cells and promote brain repair through bFGF.NATURE COMMUNICATIONS,5,5627-5627. |
| MLA | Yang, Fan,et al."Activated astrocytes enhance the dopaminergic differentiation of stem cells and promote brain repair through bFGF".NATURE COMMUNICATIONS 5(2014):5627-5627. |
入库方式： OAI收割
来源：上海神经科学研究所
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