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Proteomic Analysis of the Cerebrospinal Fluid of Parkinson's Disease Patients Pre- and Post-Deep Brain Stimulation
文献类型：期刊论文
| 作者 | Wang, Er-Song1,2; Yao, Hui-Bin1; Chen, Ying-Hui3; Wang, Gan2; Gao, Wen-Wei2; Sun, Yi-Rui4,5; Guo, Ji-Guang6; Hu, Jian-Wen7; Jiang, Cheng-Chuan1,4,5; Hu, Jin1,4,5 |
| 刊名 | CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
 |
| 出版日期 | 2013 |
| 卷号 | 31期号:4-5页码:625-637 |
| 关键词 | Cerebrospinal fluid Deep brain stimulation Parkinson's disease Proteomics |
| 英文摘要 | Aims: To investigate alterations in protein expression associated with deep brain stimulation (DBS) in an attempt to elucidate possible mechanisms of action. Methods: Crebrospinal fluid (CSF), obtained from six Parkinson's disease (PD) patients (pre- and post-DBS) and from six normal healthy controls, was studied for differentially expressed proteins. 2-D DIGE, in combination with MALDI-TOF and TOF-TOF Mass Spectrometry (MS) or ESI-MS, was used to identify the changed proteins (3 PD patients and 3 controls). Selected proteins were further studied using western blotting (6 PD patients and 6 controls). Results: Twenty-one proteins were identified after MS and protein database interrogation. Apart from apolipoprotein A-I (apoA-I), the expression levels of complement C4 (C4), IgA, tetranectin, and extracellular superoxide dismutase (EC-SOD), detected by western blotting, correlated well with the 2-D DIGE results. In the follow-up period, the expression levels of C4, apoA-I and IgA were stable whereas EC-SOD and tetranectin were significantly elevated. In addition, when DBS was ceased in one patient due to a suicide attempt, the levels of EC-SOD and tetranectin significantly decreased. Conclusion: Our preliminary results suggest that variations in the expression levels of EC-SOD and tetranectin in CSF is related to DBS. Copyright (C) 2013 S. Karger AG, Basel. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Cell Biology ; Physiology |
| 研究领域[WOS] | Cell Biology ; Physiology |
| 关键词[WOS] | EXTRACELLULAR-SUPEROXIDE DISMUTASE ; APOLIPOPROTEIN-A-I ; NEURODEGENERATIVE DISEASES ; PROTEIN AGGREGATION ; TETRANECTIN ; EXPRESSION ; SYSTEM ; PATHOGENESIS ; INSIGHTS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000322720400014 |
| 公开日期 | 2015-05-27 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/2683]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 作者单位 | 1.Fudan Univ, Jinshan Hosp, Dept Neurosurg, Shanghai 201508, Peoples R China 2.Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 6, Dept Neurosurg, Shanghai, Peoples R China 3.Fudan Univ, Jinshan Hosp, Dept Neurol, Shanghai 200433, Peoples R China 4.Fudan Univ, Huashan Hosp, Dept Neurosurg, Shanghai 200433, Peoples R China 5.Shanghai Neurosurg Ctr, Shanghai, Peoples R China 6.Chinese Acad Sci, Shanghai Inst Neurosci, Shanghai, Peoples R China 7.Chinese Acad Sci, Shanghai Inst Biol Sci, Res Ctr Proteome Anal, Shanghai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Er-Song,Yao, Hui-Bin,Chen, Ying-Hui,et al. Proteomic Analysis of the Cerebrospinal Fluid of Parkinson's Disease Patients Pre- and Post-Deep Brain Stimulation[J]. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY,2013,31(4-5):625-637. |
| APA | Wang, Er-Song.,Yao, Hui-Bin.,Chen, Ying-Hui.,Wang, Gan.,Gao, Wen-Wei.,...&Hu, Jin.(2013).Proteomic Analysis of the Cerebrospinal Fluid of Parkinson's Disease Patients Pre- and Post-Deep Brain Stimulation.CELLULAR PHYSIOLOGY AND BIOCHEMISTRY,31(4-5),625-637. |
| MLA | Wang, Er-Song,et al."Proteomic Analysis of the Cerebrospinal Fluid of Parkinson's Disease Patients Pre- and Post-Deep Brain Stimulation".CELLULAR PHYSIOLOGY AND BIOCHEMISTRY 31.4-5(2013):625-637. |
入库方式： OAI收割
来源：上海神经科学研究所
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