Cellulose-graft-poly(L-lactic acid) nanoparticles for efficient delivery of anti-cancer drugs
文献类型：期刊论文
| 作者 | Dai, Lin1; Yang, Tingyuan2; He, Jing1; Deng, Lihong1; Liu, Jing1; Wang, Luying1; Lei, Jiandu1; Wang, Lianyan2 |
| 刊名 | JOURNAL OF MATERIALS CHEMISTRY B
 |
| 出版日期 | 2014-10-21 |
| 卷号 | 2期号:39页码:6749-6757 |
| 关键词 | BETULINIC ACID MACROMOLECULAR THERAPEUTICS CARBON NANOTUBES HUMAN-MELANOMA CELLULOSE CANCER CYTOTOXICITY CELLS CARBOXYMETHYLCELLULOSE DEGRADATION |
| ISSN号 | 2050-750X |
| 其他题名 | J. Mat. Chem. B |
| 中文摘要 | Cellulose based carriers have the potential for sustained release of drugs, which can protect drugs and deliver them to the target site. Herein, BA-loaded cellulose-graft-poly(L-lactic acid) nanoparticles (CE-g-PLLA/BA NPs) were fabricated by employing cellulose (CE) and poly(L-lactic acid) (PLLA) as materials and betulinic acid (BA) as a model drug. Both drug-free and BA-loaded nanoparticles were spherical in shape with a uniform size of 100-170 nm. The release of BA from CE-g-PLLA/BA NPs was relatively slow. In vitro cytotoxicity studies with A549 and LLC cell lines suggested that CE-g-PLLA/BA NPs were slightly superior to BA in antitumor activity and CE-g-PLLA NPs were non-toxic. The antitumor effect of the CE-g-PLLA/BA NPs in a mouse tumor xenograft model exhibited much better tumor inhibition efficacy and fewer side effects than that of BA, strongly supporting their use as efficient carriers for anti-cancer therapy. |
| 英文摘要 | Cellulose based carriers have the potential for sustained release of drugs, which can protect drugs and deliver them to the target site. Herein, BA-loaded cellulose-graft-poly(L-lactic acid) nanoparticles (CE-g-PLLA/BA NPs) were fabricated by employing cellulose (CE) and poly(L-lactic acid) (PLLA) as materials and betulinic acid (BA) as a model drug. Both drug-free and BA-loaded nanoparticles were spherical in shape with a uniform size of 100-170 nm. The release of BA from CE-g-PLLA/BA NPs was relatively slow. In vitro cytotoxicity studies with A549 and LLC cell lines suggested that CE-g-PLLA/BA NPs were slightly superior to BA in antitumor activity and CE-g-PLLA NPs were non-toxic. The antitumor effect of the CE-g-PLLA/BA NPs in a mouse tumor xenograft model exhibited much better tumor inhibition efficacy and fewer side effects than that of BA, strongly supporting their use as efficient carriers for anti-cancer therapy. |
| WOS标题词 | Science & Technology ; Technology |
| 类目[WOS] | Materials Science, Biomaterials |
| 研究领域[WOS] | Materials Science |
| 关键词[WOS] | BETULINIC ACID ; MACROMOLECULAR THERAPEUTICS ; CARBON NANOTUBES ; HUMAN-MELANOMA ; CELLULOSE ; CANCER ; CYTOTOXICITY ; CELLS ; CARBOXYMETHYLCELLULOSE ; DEGRADATION |
| 收录类别 | SCI |
| 原文出处 | |
| 语种 | 英语 |
| WOS记录号 | WOS:000342856400008 |
| 公开日期 | 2014-12-01 |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/11672]  |
| 专题 | 过程工程研究所_研究所（批量导入） |
| 作者单位 | 1.Beijing Forestry Univ, MOE Key Lab Wooden Mat Sci & Applicat, Beijing 100083, Peoples R China 2.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Dai, Lin,Yang, Tingyuan,He, Jing,et al. Cellulose-graft-poly(L-lactic acid) nanoparticles for efficient delivery of anti-cancer drugs[J]. JOURNAL OF MATERIALS CHEMISTRY B,2014,2(39):6749-6757. |
| APA | Dai, Lin.,Yang, Tingyuan.,He, Jing.,Deng, Lihong.,Liu, Jing.,...&Wang, Lianyan.(2014).Cellulose-graft-poly(L-lactic acid) nanoparticles for efficient delivery of anti-cancer drugs.JOURNAL OF MATERIALS CHEMISTRY B,2(39),6749-6757. |
| MLA | Dai, Lin,et al."Cellulose-graft-poly(L-lactic acid) nanoparticles for efficient delivery of anti-cancer drugs".JOURNAL OF MATERIALS CHEMISTRY B 2.39(2014):6749-6757. |
入库方式： OAI收割
来源：过程工程研究所
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