Preparation of uniform-sized colloidosomes based on chitosan-coated alginate particles and its application for oral insulin delivery
文献类型：期刊论文
| 作者 | Nan, Fangfang1,3; Wu, Jie1; Qi, Feng1,3; Fan, Qingze1,3; Ma, Guanghui1; Ngai, To2 |
| 刊名 | JOURNAL OF MATERIALS CHEMISTRY B
 |
| 出版日期 | 2014 |
| 卷号 | 2期号:42页码:7403-7409 |
| 关键词 | PREMIX MEMBRANE EMULSIFICATION NANOPARTICLE COLLOIDOSOMES MULTIPLE EMULSIONS MICROCAPSULES LIPOSOMES RELEASE |
| ISSN号 | 2050-750X |
| 其他题名 | J. Mat. Chem. B |
| 中文摘要 | Colloidosomes are microcapsules that consist of a hollow core coated by a shell composed of self-assembled colloidal particles. In recent years, they have attracted significant attention as potential vehicles for the controlled delivery of active ingredients. A key challenge in such applications is the production of uniform-sized colloidosomes for the encapsulation of active ingredients such that the actual delivery amount can be well controlled. Based on our previous study on an ethyl acetate-in-water emulsion stabilized by chitosan-coated alginate particles, we further prepared monodisperse colloidosomes with a high yield and low permeability by combining the premix membrane emulsification technique and polymer deposition method. The potential application of the formed colloidosomes as oral insulin delivery vehicles was investigated. Our results revealed that in comparison to conventional PLGA microspheres, the formulated colloidosomes showed high drug encapsulation efficiency (up to 96.7%) and an obvious pH sensitive release profile. Moreover, in animal testing, the colloidosomes formulation achieved a long-term hypoglycemic effect up to 6 h, which confirmed its application as an oral drug delivery system. |
| 英文摘要 | Colloidosomes are microcapsules that consist of a hollow core coated by a shell composed of self-assembled colloidal particles. In recent years, they have attracted significant attention as potential vehicles for the controlled delivery of active ingredients. A key challenge in such applications is the production of uniform-sized colloidosomes for the encapsulation of active ingredients such that the actual delivery amount can be well controlled. Based on our previous study on an ethyl acetate-in-water emulsion stabilized by chitosan-coated alginate particles, we further prepared monodisperse colloidosomes with a high yield and low permeability by combining the premix membrane emulsification technique and polymer deposition method. The potential application of the formed colloidosomes as oral insulin delivery vehicles was investigated. Our results revealed that in comparison to conventional PLGA microspheres, the formulated colloidosomes showed high drug encapsulation efficiency (up to 96.7%) and an obvious pH sensitive release profile. Moreover, in animal testing, the colloidosomes formulation achieved a long-term hypoglycemic effect up to 6 h, which confirmed its application as an oral drug delivery system. |
| WOS标题词 | Science & Technology ; Technology |
| 类目[WOS] | Materials Science, Biomaterials |
| 研究领域[WOS] | Materials Science |
| 关键词[WOS] | PREMIX MEMBRANE EMULSIFICATION ; NANOPARTICLE COLLOIDOSOMES ; MULTIPLE EMULSIONS ; MICROCAPSULES ; LIPOSOMES ; RELEASE |
| 收录类别 | SCI |
| 原文出处 | |
| 语种 | 英语 |
| WOS记录号 | WOS:000343038600013 |
| 公开日期 | 2014-12-01 |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/11683]  |
| 专题 | 过程工程研究所_研究所（批量导入） |
| 作者单位 | 1.Chinese Acad Sci, Inst Proc Engn, Key Lab Biopharmaceut Prod & Formulat Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China 2.Chinese Univ Hong Kong, Dept Chem, Shatin, Hong Kong, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Nan, Fangfang,Wu, Jie,Qi, Feng,et al. Preparation of uniform-sized colloidosomes based on chitosan-coated alginate particles and its application for oral insulin delivery[J]. JOURNAL OF MATERIALS CHEMISTRY B,2014,2(42):7403-7409. |
| APA | Nan, Fangfang,Wu, Jie,Qi, Feng,Fan, Qingze,Ma, Guanghui,&Ngai, To.(2014).Preparation of uniform-sized colloidosomes based on chitosan-coated alginate particles and its application for oral insulin delivery.JOURNAL OF MATERIALS CHEMISTRY B,2(42),7403-7409. |
| MLA | Nan, Fangfang,et al."Preparation of uniform-sized colloidosomes based on chitosan-coated alginate particles and its application for oral insulin delivery".JOURNAL OF MATERIALS CHEMISTRY B 2.42(2014):7403-7409. |
入库方式： OAI收割
来源：过程工程研究所
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