Tumor Necrosis Factor Receptor 2 (TNFR2)center dot Interleukin-17 Receptor D (IL-17RD) Heteromerization Reveals a Novel Mechanism for NF-kappa B Activation
文献类型：期刊论文
| 作者 | Yang, S. G.; Wang, Y. Y.; Mei, K. R.; Zhang, S.; Sun, X. J.; Ren, F. L.; Liu, S. H.; Yang, Z.; Wang, X. Q.; Qin, Z. H. |
| 刊名 | Journal of Biological Chemistry
 |
| 出版日期 | 2015 |
| 期号 | 2页码:861-871 |
| 关键词 | TNF RECEPTOR LIGAND CELLS KINASE KIDNEY ALPHA HSEF SEF LOCALIZATION INFLAMMATION |
| 其他题名 | J. Biol. Chem. |
| 中文摘要 | TNF receptor 2 (TNFR2) exerts diverse roles in the pathogenesis of inflammatory and autoimmune diseases. Here, we report that TNFR2 but not TNFR1 forms a heteromer with interleukin-17 receptor D (IL-17RD), also named Sef, to activate NF-kappa B signaling. TNFR2 associates with IL-17RD, leading to mutual receptor aggregation and TRAF2 recruitment, which further activate the downstream cascade of NF-kappa B signaling. Depletion of IL-17RD impaired TNFR2-mediated activation of NF-kappa B signaling. Importantly, IL-17RD was markedly increased in renal tubular epithelial cells in nephritis rats, and a strong interaction of TNFR2 and IL-17RD was observed in the renal epithelia. The IL-17RD center dot TNFR2 complex in activation of NF-kappa B may explain the role of TNFR2 in inflammatory diseases including nephritis. |
| 收录类别 | SCI |
| 原文出处 | |
| 语种 | 英语 |
| WOS记录号 | WOS:000347778200016 |
| 公开日期 | 2015-04-01 |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/11873]  |
| 专题 | 过程工程研究所_研究所（批量导入） |
| 推荐引用方式 GB/T 7714 | Yang, S. G.,Wang, Y. Y.,Mei, K. R.,et al. Tumor Necrosis Factor Receptor 2 (TNFR2)center dot Interleukin-17 Receptor D (IL-17RD) Heteromerization Reveals a Novel Mechanism for NF-kappa B Activation[J]. Journal of Biological Chemistry,2015(2):861-871. |
| APA | Yang, S. G..,Wang, Y. Y..,Mei, K. R..,Zhang, S..,Sun, X. J..,...&Chang, Z. J..(2015).Tumor Necrosis Factor Receptor 2 (TNFR2)center dot Interleukin-17 Receptor D (IL-17RD) Heteromerization Reveals a Novel Mechanism for NF-kappa B Activation.Journal of Biological Chemistry(2),861-871. |
| MLA | Yang, S. G.,et al."Tumor Necrosis Factor Receptor 2 (TNFR2)center dot Interleukin-17 Receptor D (IL-17RD) Heteromerization Reveals a Novel Mechanism for NF-kappa B Activation".Journal of Biological Chemistry .2(2015):861-871. |
入库方式： OAI收割
来源：过程工程研究所
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