Development of pneumococcal polysaccharide conjugate vaccine with long spacer arm
文献类型：期刊论文
| 作者 | Wu, Dinglong1,2; Ji, Shaoyang1; Hu, Tao1 |
| 刊名 | VACCINE
 |
| 出版日期 | 2013-11-19 |
| 卷号 | 31期号:48页码:5623-5626 |
| 关键词 | Streptococcus pneumoniae Capsular polysaccharide Conjugate vaccine Azide-alkyne cycloaddition |
| ISSN号 | 0264-410X |
| 英文摘要 | Streptococcus pneumoniae is a serious Gram-positive pathogen responsible for several life-threatening pneumococcal diseases. Pneumococcal capsular polysaccharide (CPS) is a key virulence determinant of S. pneumoniae and its immunogenicity can be improved by conjugation with a carrier protein. Reductive amination, the most widely used approach for pneumococcal CPS conjugate vaccine (PCV), suffers from low conjugation efficiency and the problem of steric hindrance. Here, copper-catalyzed azide-alkyne cycloaddition was used for development of PCV with long spacer arm (L-PCV). Tetanus toxoid (TT) was used as the carrier protein. The long spacer arm in L-PCV can minimize the problem of steric hindrance between CPS and IT, thereby improving the CPS-specific antibody titers in the mice model. L-PCV can also induce high avidity functional antibody and elicit immunological memory in response to the native CPS. (C) 2013 Elsevier Ltd. All rights reserved. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Immunology ; Medicine, Research & Experimental |
| 研究领域[WOS] | Immunology ; Research & Experimental Medicine |
| 关键词[WOS] | STREPTOCOCCUS-PNEUMONIAE ; IMMUNOGENICITY ; EPITOPE ; ADULTS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000327580300001 |
| 公开日期 | 2015-05-27 |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/13329]  |
| 专题 | 过程工程研究所_研究所（批量导入） |
| 作者单位 | 1.Chinese Acad Sci, Natl Key Lab Biochem Engn, Inst Proc Engn, Beijing 100190, Peoples R China 2.Fujian Agr & Forestry Univ, Coll Life Sci, Fuzhou 350002, Fujian Province, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wu, Dinglong,Ji, Shaoyang,Hu, Tao. Development of pneumococcal polysaccharide conjugate vaccine with long spacer arm[J]. VACCINE,2013,31(48):5623-5626. |
| APA | Wu, Dinglong,Ji, Shaoyang,&Hu, Tao.(2013).Development of pneumococcal polysaccharide conjugate vaccine with long spacer arm.VACCINE,31(48),5623-5626. |
| MLA | Wu, Dinglong,et al."Development of pneumococcal polysaccharide conjugate vaccine with long spacer arm".VACCINE 31.48(2013):5623-5626. |
入库方式： OAI收割
来源：过程工程研究所
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